دورية أكاديمية
Epigenetic clocks in relapse after a first episode of schizophrenia
| العنوان: | Epigenetic clocks in relapse after a first episode of schizophrenia |
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| المؤلفون: | González Segura, Álex, Prohens, Llucia, Mezquida, G., Amoretti, Silvia, Bioque, Miquel, Ribeiro, M., Gurriarán-Bas, Xaquin, Rementería, Lide, Berge, Daniel, Rodriguez-Jimenez, R., Roldán, Alexandra, Pomarol-Clotet, Edit, Ibáñez, Angela, Usall, J., García Portilla, María Paz, Cuesta, Manuel J., Parellada, M., González-Pinto, A., Berrocoso Domínguez, Esther María, Bernardo, Miquel, Mas, Sergi, 2EPS group |
| المساهمون: | Psicología |
| المصدر: | Schizophrenia, Vol. 8, Núm. 1 |
| بيانات النشر: | SPRINGERNATURE |
| سنة النشر: | 2023 |
| المجموعة: | RODIN - Repositorio de Objetos de Docencia e Investigación de la Universidad de Cádiz |
| الوصف: | The main objective of the present study was to investigate the association between several epigenetic clocks, covering different aspects of aging, with schizophrenia relapse evaluated over a 3-year follow-up period in a cohort of ninety-one first-episode schizophrenia patients. Genome-wide DNA methylation was profiled and four epigenetic clocks, including epigenetic clocks of chronological age, mortality and telomere length were calculated. Patients that relapsed during the follow-up showed epigenetic acceleration of the telomere length clock (p=0.030). Shorter telomere length was associated with cognitive performance (working memory, r=0.31 p=0.015; verbal fluency, r=0.28 p=0.028), but no direct effect of cognitive function or symptom severity on relapse was detected. The results of the present study suggest that epigenetic age acceleration could be involved in the clinical course of schizophrenia and could be a useful marker of relapse when measured in remission stages. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2754-6993 |
| العلاقة: | info:eu-repo/grantAgreement/MINECO//PI14%2F00612/ES/Estudio de aplicabilidad clínica de un modelo predictivo de recaídas en primeros episodios de esquizofrenia/; http://hdl.handle.net/10498/27935Test |
| DOI: | 10.1038/s41537-022-00268-2 |
| الإتاحة: | https://doi.org/10.1038/s41537-022-00268-2Test http://hdl.handle.net/10498/27935Test |
| حقوق: | Atribución 4.0 Internacional ; http://creativecommons.org/licenses/by/4.0Test/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.463DEDC4 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 27546993 |
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| DOI: | 10.1038/s41537-022-00268-2 |