The Alternating Access Transport Mechanism in LacY
| العنوان: | The Alternating Access Transport Mechanism in LacY |
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| المؤلفون: | H. Ronald Kaback, Yiling Nie, Yonggang Zhou, Irina Smirnova, Vladimir N. Kasho |
| المصدر: | The Journal of Membrane Biology Kaback, H. Ronald; Smirnova, Irina; Kasho, Vladimir; Nie, Yiling; & Zhou, Yonggang. (2011). The Alternating Access Transport Mechanism in LacY. The Journal of Membrane Biology, 239(1), pp 85-93. doi: 10.1007/s00232-010-9327-5. Retrieved from: http://www.escholarship.org/uc/item/6j14q3xsTest |
| بيانات النشر: | Springer-Verlag, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Lactose permease, Models, Molecular, Conformational change, Alkylation, Monosaccharide Transport Proteins, Physiology, Protein Conformation, Biophysics, Transport, Lactose, Article, 03 medical and health sciences, 0302 clinical medicine, Protein structure, Symport, Cysteine, Permease, 030304 developmental biology, 0303 health sciences, Symporters, Chemistry, Escherichia coli Proteins, Membrane, Tryptophan, Life Sciences, Biological Transport, Cell Biology, Sugar binding, Biochemistry, general, Human Physiology, Biochemistry, Membrane protein, Symporter, 030217 neurology & neurosurgery |
| الوصف: | Lactose permease of Escherichia coli (LacY) is highly dynamic, and sugar binding causes closing of a large inward-facing cavity with opening of a wide outward-facing hydrophilic cavity. Therefore, lactose/H(+) symport via LacY very likely involves a global conformational change that allows alternating access of single sugar- and H(+)-binding sites to either side of the membrane. Here, in honor of Stephan H. White's seventieth birthday, we review in camera the various biochemical/biophysical approaches that provide experimental evidence for the alternating access mechanism. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1432-1424 0022-2631 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a837ce77281d92027d014672c6b94933Test http://europepmc.org/articles/PMC3030946Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a837ce77281d92027d014672c6b94933 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14321424 00222631 |
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