التفاصيل البيبلوغرافية
| العنوان: |
Pertuzumab, trastuzumab and taxane-based treatment for visceral organ metastatic, trastuzumab-naïve breast cancer: real-life practice outcomes |
| المؤلفون: |
Esin, E., Oksuzoglu, B., Bilici, A., Cicin, I., Kostek, O., Kaplan, M.A., Aksoy, S., Aktas, B.Y., Ozdemir, O., Alacacioglu, A., Cabuk, D., Sumbul, A.T., Sakin, A., Paydas, S., Yetisir, E., Er, O., Korkmaz, T., Yildirim, N., Sakalar, T., Demir, H., Artac, M., Karaagac, M., Harputluoglu, H., Bilen, E., Erdur, E., Değirmencioğlu, Serkan, Aliyev, A., Cil, T., Olgun, P., Basaran, G., Gumusay, O., Demir, A., Tanrikulu, E., Yumuk, P.F., Imamoglu, I., Oyan, B., Cetin, B., Haksoyler, V., Karadurmus, N., Erturk, I., Evrensel, T., Yilmaz, H., Beypinar, I., Kocer, M., Pilanci, K.N., Seker, M., Urun, Y., Eren, T., Demirci, U., Uluc Oyan, B., Beypinar, Kocer, Turkish Oncology Group |
| بيانات النشر: |
Springer Verlag, 2019. |
| سنة النشر: |
2019 |
| مصطلحات موضوعية: |
vomiting, loading drug dose, myalgia, peripheral neuropathy, retrospective study, very elderly, diarrhea, clinical outcome, thrombocytopenia, rash, Docetaxel, AntiHER2, paclitaxel, middle aged, Antineoplastic Combined Chemotherapy Protocols, brain metastasis, Neoplasm Metastasis, Practice Patterns, Physicians', cancer survival, Visceral metastasis, antineoplastic agent, Aged, 80 and over, progression free survival, breast tumor, adult, lung metastasis, Carcinoma, Ductal, Breast, Prognosis, clinical practice, Survival Rate, trastuzumab, aged, female, priority journal, Paget nipple disease, young adult, mucosa inflammation, blood transfusion reaction, hyperbilirubinemia, side effect, overall survival, lobular carcinoma, Breast Neoplasms, Antibodies, Monoclonal, Humanized, cancer prognosis, Article, multiple cycle treatment, transthoracic echocardiography, pertuzumab, cancer combination chemotherapy, hypokalemia, neutropenia, follow up, metastasis, Humans, Neoplasm Invasiveness, human, arthralgia, human epidermal growth factor receptor 2 positive breast cancer, Retrospective Studies, hypertransaminasemia, tumor invasion, major clinical study, mortality, liver metastasis, Carcinoma, Lobular, monoclonal antibody, epidermal growth factor receptor 2, fatigue, pathology, heart left ventricle ejection fraction, Follow-Up Studies |
| الوصف: |
Purpose: In this study, we aimed to describe the real-life practice outcomes of pertuzumab–trastuzumab–taxane (PTT) combination in visceral organ metastatic, trastuzumab-naive breast cancer (BC) patients. Methods: This study was conducted by Turkish Oncology Group and included 317 patients’ data from 36 centers. Results: Median age was 51 (22–82). Median PFS was 28.5 months, while median OS was 40.3 months. Patients with brain metastases (n: 13, 4.1%) had worse PFS (16.8 m vs. 28.5 m; p = 0.002) and OS (26.7 m vs. 40.3 m; p = 0.009). Patients older than 65 years of age (n: 42, 13.2%) had significantly lower OS results (19.8 m vs. 40.3 m; p = 0.01). Two hundred sixty-eight patients (86.7%) received docetaxel while 37 patients (11.7%) received paclitaxel. PFS and OS were similar between taxane groups. In eight patients (2.5%), 5–40% ejection fraction decrement from baseline was detected without any clinical sign of heart failure. Conclusions: Our RLP trial included only visceral metastatic, trastuzumab-naïve BC patients including cases with brain involvement who received PTT combination in the first-line treatment. Regardless of negative prognostic characteristics, our results are in parallel with pivotal trial. Further strategies for brain metastasis should be developed to improve outcomes despite encouraging results with PTT treatment. Taxane selection can be personalized and endocrine maintenance may further improve outcomes after taxanes were discontinued. To our knowledge, this is the largest scale real-life clinical practice study of pertuzumab–trastuzumab–taxane therapy to date. © 2018, Springer-Verlag GmbH Germany, part of Springer Nature. |
| اللغة: |
English |
| الوصول الحر: |
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::55afbbbbf63f738fa7caa21653d38190Test |
| حقوق: |
OPEN |
| رقم الانضمام: |
edsair.dedup.wf.001..55afbbbbf63f738fa7caa21653d38190 |
| قاعدة البيانات: |
OpenAIRE |
