دورية أكاديمية
Neuroprotective effects of curcumin against acetamiprid-induced neurotoxicity and oxidative stress in the developing male rat cerebellum: biochemical, histological, and behavioral changes.
| العنوان: | Neuroprotective effects of curcumin against acetamiprid-induced neurotoxicity and oxidative stress in the developing male rat cerebellum: biochemical, histological, and behavioral changes. |
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| المؤلفون: | Dhouib, Ines Bini, Annabi, Alya, Doghri, Raoudha, Rejeb, Ines, Dallagi, Yosra, Bdiri, Yassin, Lasram, Mohamed Montassar, Elgaaied, Amel, Marrakchi, Raja, Fazaa, Saloua, Gati, Asma |
| المساهمون: | Laboratoire d'immunologie clinique Institut Pasteur de Tunis, Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), laboratory of Aggression Physiology and Endocrine Metabolic Studies, Department of Biology, Faculty of Sciences, Tunis, Tunisia, aboratory of Aggression Physiology and Endocrine Metabolic Studies, Department of Biology, Faculty of Sciences, Tunis, Tunisia, Laboratory of Genetics, Immunology and Human Pathology Tunis,Tunisie, Université de Tunis El Manar (UTM)-Faculty of Sciences of Tunis, Laboratory of Genetics, Immunology and Human Pathology |
| المصدر: | ISSN: 0944-1344. |
| بيانات النشر: | HAL CCSD Springer Verlag |
| سنة النشر: | 2017 |
| المجموعة: | Réseau International des Instituts Pasteur, Paris: HAL-RIIP |
| مصطلحات موضوعية: | Acetamiprid, Cerebellum, Curcumin, Necrosis, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| الوصف: | International audience ; Curcumin is a molecule found in turmeric root that has anti-inflammatory, antioxidant, and anti-tumor properties and has been widely used as both an herbal drug and a food additive to treat or prevent neurodegenerative diseases. This study aimed to investigate the effect of curcumin on neurobehavioral and neuropathological alterations induced by acetamiprid on male rats. Three groups of ten male Wistar rats each were used for the study: the first was a control group (CTR) that did not consume acetamiprid (ACE); the second was an experimental group (ACE) that consumed 40 mg/kg body weight/day of acetamiprid; and the third group (CUR) received curcumin (100 mg/kg) and acetamiprid (40 mg/kg) in combination. Neurobehavioral evaluations including inclined plane performance and forepaw grip time were studied. Treatment with CUR significantly prevented ACE-treated rats from impairments in the performance of neurobehavioral tests, indicating the presence of deficits on sensorimotor and neuromuscular responses. In addition, Curcumin administration protects rats against acetamiprid-induced cerebellum toxicity such as increase in AChE and BChE activities, decrease on cells viability, oxidative stress, and an increase of intracellular calcium. Taken together, these results demonstrate for the first time that ACE treatment substantially impairs the survival of primary neuronal cells through the induction of necrosis concomitantly with the generation of an oxidative stress. Additionally, curcumin reduced histopathological changes caused by ACE. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/28980111; hal-01876293; https://hal.science/hal-01876293Test; PUBMED: 28980111 |
| DOI: | 10.1007/s11356-017-0331-5 |
| الإتاحة: | https://doi.org/10.1007/s11356-017-0331-5Test https://hal.science/hal-01876293Test |
| رقم الانضمام: | edsbas.97E33443 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s11356-017-0331-5 |
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