Potential Effects of Mina53 on Tumor Growth in Human Pancreatic Cancer
| العنوان: | Potential Effects of Mina53 on Tumor Growth in Human Pancreatic Cancer |
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| المؤلفون: | Zi-Rong Yang, Weiguo Dong, Qing-qing Zhang, Xiao-Ping Tan, Ming-Hua Ai, Xiao-Fei Lei |
| المصدر: | Cell Biochemistry and Biophysics |
| بيانات النشر: | Springer US, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, Pathology, medicine.medical_specialty, Biophysics, Apoptosis, Biology, Biochemistry, Dioxygenases, RNA interference, Antigen, Pancreatic cancer, Cell Line, Tumor, medicine, Biomarkers, Tumor, Humans, Nuclear protein, RNA, Small Interfering, Lymph node, Tumor growth, Cell Proliferation, Neoplasm Staging, Histone Demethylases, Original Paper, Mina53, Cell growth, Quantum dots, Nuclear Proteins, Cell Biology, General Medicine, Middle Aged, medicine.disease, Gene Expression Regulation, Neoplastic, Pancreatic Neoplasms, medicine.anatomical_structure, Lymphatic Metastasis, CA19-9, Female |
| الوصف: | Myc-induced nuclear antigen (Mina53) is a protein with a molecular weight of 53 kDa expression of which is induced by c-Myc. Increased expression of Mina53 is documented in some human carcinomas. In this study, we found markedly increased Mina53 expression in pancreatic cancer tissue specimens. This expression did not correlate with clinicopathological characteristics, such as sex, age, and presence of distant metastasis. However, there was a statistically significant association with histological differentiation, TNM stage, and lymph node metastases. To study functional role of Mina53, we silenced its expression by siRNA in PANC-1 cells. These cells were arrested in the G2/M phase, and apoptosis rates were increased. In conclusion, increased expression of Mina53 may play an important role in the development of human pancreatic cancer. Mina53 can be used as a marker for pancreatic cancer and may potentially be exploited as a target for treatment of pancreatic cancer. |
| اللغة: | English |
| تدمد: | 1559-0283 1085-9195 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::428c34658dc121d7ae95755ddf719febTest http://europepmc.org/articles/PMC4057634Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....428c34658dc121d7ae95755ddf719feb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15590283 10859195 |
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