Content of Carbonyl Compounds and Parameters of Glutathione Metabolism in Men with Type 1 Diabetes Mellitus at Preclinical Stages of Diabetic Nephropathy
| العنوان: | Content of Carbonyl Compounds and Parameters of Glutathione Metabolism in Men with Type 1 Diabetes Mellitus at Preclinical Stages of Diabetic Nephropathy |
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| المؤلفون: | Lyudmila Grebenkina, Sergey I. Kolesnikov, M. A. Darenskaya, Lyubov Kolesnikova, E. V. Chugunova, Natalya Semenova, O. A. Nikitina |
| المصدر: | Bulletin of Experimental Biology and Medicine |
| بيانات النشر: | Springer US, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Glutathione metabolism, Adult, Male, medicine.medical_specialty, microalbuminuria, Adolescent, Free Radicals, Renal function, men, Prodromal Symptoms, Thiobarbituric Acid Reactive Substances, General Biochemistry, Genetics and Molecular Biology, Article, Russia, Diabetic nephropathy, chemistry.chemical_compound, Young Adult, Internal medicine, medicine, Albuminuria, Humans, Diabetic Nephropathies, chemistry.chemical_classification, Type 1 diabetes, Chemistry, Methylglyoxal, General Medicine, Glutathione, medicine.disease, Pyruvaldehyde, carbonyl compounds, Oxidative Stress, Endocrinology, Enzyme, Diabetes Mellitus, Type 1, Case-Control Studies, Asymptomatic Diseases, glutathione-dependent enzymes, Microalbuminuria, type 1 diabetes mellitus, Glomerular Filtration Rate |
| الوصف: | The content of carbonyl compounds (methylglyoxal and TBA-reactive substances) and components of the glutathione system (activities of glutathione-dependent enzymes, content of oxidized and reduced glutathione) and their interrelationships were studied in men of young reproductive age with type 1 diabetes mellitus at the stages of normo- and microalbuminuria. In patients with normoalbuminuria, the level of methylglyoxal, reduced and oxidized glutathione, and glutathione reductase activity were increased and the content of TBA-reactive substances was decreased. In the group with microalbuminuria, an increase in content of methylglyoxal and activity of glutathione-dependent enzymes relative to the control values were observed; the content of TBA-reactive substances was increased and glutathione reductase activity was decreased relative to the group with normoalbuminuria. In patients with microalbuminuria, a strong correlation between the mean glomerular filtration rate and the blood level of methylglyoxal was revealed. |
| اللغة: | English |
| تدمد: | 1573-8221 0007-4888 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ea56c9825d35b57a80342300105c960Test http://europepmc.org/articles/PMC8494601Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3ea56c9825d35b57a80342300105c960 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15738221 00074888 |
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