Clinical Challenges in an Outbreak of COVID-19 in Wuhan, China: Concerns from Frontiers
| العنوان: | Clinical Challenges in an Outbreak of COVID-19 in Wuhan, China: Concerns from Frontiers |
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| المؤلفون: | Yao Wang, Zuojiong Gong, Xun Li, Luwen Wang |
| المصدر: | Current Infectious Disease Reports |
| بيانات النشر: | Springer US, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Tropical, Travel and Emerging Infections (L Chen and A Boggild,Section Editors), business.industry, Transmission (medicine), SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), 030106 microbiology, Gold standard, Outbreak, COVID-19, medicine.disease, 03 medical and health sciences, Pneumonia, 0302 clinical medicine, medicine.anatomical_structure, Infectious Diseases, Clinical challenges, medicine, 030212 general & internal medicine, Cytokine storm, Intensive care medicine, business, Respiratory tract |
| الوصف: | Purpose of Review In December 2019, outbreaks of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected pneumonia patients were discovered in Wuhan City, Hubei Province, China. With the spread of the epidemic, new cases have been found in other regions of China and abroad. This review summarizes the current coronavirus disease 2019 (COVID-19) transmission pathways, high-risk factors, diagnostic points, pathogenesis, and therapeutic drugs to provide the prevention and treatment theories for COVID-19. Recent Findings COVID-19 is highly contagious and is transmitted mainly through the respiratory tract. Most patients with SARS-CoV-2 infection have milder symptoms. Some patients will have mild disease in the early stage, suddenly exacerbate later, and eventually die of multiple organ failure caused by cytokine storm. The basis for clinical diagnosis of COVID-19 is not just the detection of viral nucleic acids as the gold standard. The diagnostic accuracy improves when viral nucleic acid test is combined with clinical symptoms, CT results, and biochemical tests. For the treatment of COVID-19, the specific antiviral agents have not been developed, except for symptomatic supportive treatments. Summary The methods for detecting SARS-CoV-2 infection have become increasingly mature, but specific antiviral drugs for the treatment of COVID-19 have not yet been developed. Treatment must pay attention to the cytokine storm that leads to the seriousness of COVID-19. |
| اللغة: | English |
| تدمد: | 1534-3146 1523-3847 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bad4ad801e99a0f2a99310db7b7eb24Test http://europepmc.org/articles/PMC7508676Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7bad4ad801e99a0f2a99310db7b7eb24 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15343146 15233847 |
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