Accuracy of CT Pulmonary Artery Diameter for Pulmonary Hypertension in End-Stage COPD
| العنوان: | Accuracy of CT Pulmonary Artery Diameter for Pulmonary Hypertension in End-Stage COPD |
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| المؤلفون: | Esther Pompe, Tim Besselink, Erik Jan D Oudijk, Ed A. van de Graaf, Pim A. de Jong, Bart Luijk, J.M. Kwakkel-van Erp, Firdaus A. A. Mohamed Hoesein |
| المصدر: | Lung Lung, 194(5), 813. Springer New York |
| بيانات النشر: | Springer US, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Spirometry, Pulmonary and Respiratory Medicine, Male, medicine.medical_specialty, medicine.medical_treatment, Hypertension, Pulmonary, 030204 cardiovascular system & hematology, Pulmonary Artery, Article, Pulmonary function testing, 03 medical and health sciences, Pulmonary Disease, Chronic Obstructive, 0302 clinical medicine, Predictive Value of Tests, Internal medicine, medicine.artery, Forced Expiratory Volume, medicine, Journal Article, Radiology and other imaging, Lung transplantation, COPD, Humans, Arterial Pressure, Aorta, Aged, Retrospective Studies, medicine.diagnostic_test, business.industry, Pulmonary circulation and pulmonary hypertension, Organ Size, Middle Aged, medicine.disease, Pulmonary hypertension, 030228 respiratory system, Predictive value of tests, Heart catheterization, Pulmonary artery, Cardiology, Female, business, Tomography, X-Ray Computed |
| الوصف: | INTRODUCTION: Pulmonary hypertension (PH) in COPD is associated with a higher mortality and an increased risk on exacerbations compared to COPD patients without PH. The aim was to evaluate the diagnostic value of pulmonary artery (PA) measurements on chest computed tomography (CT) for PH in end-stage COPD. METHODS: COPD patients evaluated for eligibility for lung transplantation between 2004 and 2015 were retrospectively analyzed. Clinical characteristics, chest CTs, spirometry, and right-sided heart catheterizations (RHC) were studied. Diameters of PA and ascending aorta (A) were measured on CT. Diagnostic properties of different cut-offs of PA diameter and PA:A ratio in diagnosing PH were calculated. RESULTS: Of 92 included COPD patients, 30 (32.6 %) had PH at RHC (meanPAP > 25 mm Hg). PA:A > 1 had a negative predictive value (NPV) of 77.9 % and a positive predictive value (PPV) of 63.1 % with an odds ratio (OR (CI 95 %)) of 5.60 (2.00-15.63). PA diameter ≥30 mm had a NPV of 78 % and PPV of 64 % with an OR (CI 95 %) of 6.95 (2.51-19.24). CONCLUSION: A small PA diameter and PA:A make the presence of PH unlikely but cannot exclude its presence in end-stage COPD. A large PA diameter and PA:A maybe used to detect PH early. |
| وصف الملف: | image/pdf |
| اللغة: | English |
| تدمد: | 1432-1750 0341-2040 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8e976cdb415f805919040169e9a5c82Test http://europepmc.org/articles/PMC5031745Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e8e976cdb415f805919040169e9a5c82 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14321750 03412040 |
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