Metabolic syndrome and early stage breast cancer outcome: results from a prospective observational study
| العنوان: | Metabolic syndrome and early stage breast cancer outcome: results from a prospective observational study |
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| المؤلفون: | Giuseppe Buono, Sabino De Placido, Aldo Giudice, Pietro De Placido, Alfonso Amore, Meghana V. Trivedi, Rossella Lauria, Carmine De Angelis, Giuseppe Porciello, Mario Giuliano, Grazia Arpino, Carmen Pacilio, Valeria Forestieri, Anna Crispo, Emanuela Esposito, Anita Minopoli, Maria Grazia Grimaldi, Michelino De Laurentiis, Carmen G. Rea, Francesco Schettini, Gerardo Botti, Flavia Nocerino |
| المساهمون: | Buono, G., Crispo, A., Giuliano, M., De Angelis, C., Schettini, F., Forestieri, V., Lauria, R., De Laurentiis, M., De Placido, P., Rea, C. G., Pacilio, C., Esposito, E., Grimaldi, M., Nocerino, F., Porciello, G., Giudice, A., Amore, A., Minopoli, A., Botti, G., De Placido, S., Trivedi, M. V., Arpino, G. |
| المصدر: | Breast Cancer Research and Treatment |
| بيانات النشر: | Springer US, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Cancer Research, medicine.medical_specialty, Waist, Multivariate analysis, Breast Neoplasms, Comorbidity, Risk Assessment, Disease-Free Survival, Insulin resistance, Breast cancer, Breast cancer outcome, Risk Factors, Internal medicine, medicine, Humans, Metabolic syndrome components, Prospective Studies, Prospective cohort study, Metabolic Syndrome, business.industry, Hazard ratio, Age Factors, Middle Aged, medicine.disease, Clinical Trial, Oncology, Population study, Female, Metabolic syndrome, Waist Circumference, business, Follow-Up Studies |
| الوصف: | Purpose Obesity and insulin resistance have been associated with poor prognosis in breast cancer (BC). The present prospective study aimed to investigate the impact of metabolic syndrome (MetS) and its components on early BC (eBC) patients’ outcome. Methods MetS was defined by the presence of 3 to 5 of the following components: waist circumference > 88 cm, blood pressure ≥ 130/≥ 85 mmHg, serum levels of triglycerides ≥ 150 mg/dL, high density lipoprotein . Results Overall, 544 (75.9%) and 173 (24.1%) women were categorized as non-MetS and MetS, respectively. MetS patients were more likely to be older, postmenopausal, and insulin-resistant compared to non-MetS patients (p p = 0.07] and a significantly higher risk of death compared to non-MetS patients [overall survival (OS), HR 3.01, p p = 0.001]. Additionally, patients with 1 to 2 components of MetS had an increased risk of dying compared to patients with 0 components (OS, HR 4.90, p = 0.01; BCSS, HR 6.07, p = 0.02). Conclusions MetS correlated with poor outcome in eBC patients. Among patients without full criteria for MetS diagnosis, the presence of 1 or 2 components of the syndrome may predict for worse survival. |
| اللغة: | English |
| تدمد: | 1573-7217 0167-6806 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be608ac75c5f27e092a206b8081f8c17Test http://europepmc.org/articles/PMC7297840Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....be608ac75c5f27e092a206b8081f8c17 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15737217 01676806 |
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