Association of a polymorphism in the indoleamine- 2,3-dioxygenase gene and interferon-α-induced depression in patients with chronic hepatitis C
| العنوان: | Association of a polymorphism in the indoleamine- 2,3-dioxygenase gene and interferon-α-induced depression in patients with chronic hepatitis C |
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| المؤلفون: | Jason S. Simon, Alicia K. Smith, Andrew H. Miller, Clifford A. Brass, Michael P. Epstein, Ping Qiu, David James Devlin, Eric L. Gustafson, Mark S. Sulkowski, Stephanie Noviello, Joseph F. Cubells, John G. McHutchinson, Janice K. Albrecht |
| المصدر: | Molecular psychiatry |
| بيانات النشر: | Springer Science and Business Media LLC, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Genotype, Alpha interferon, Locus (genetics), Single-nucleotide polymorphism, Interferon alpha-2, indoleamine-2, Biology, Antiviral Agents, Gastroenterology, White People, Article, Polyethylene Glycols, Cellular and Molecular Neuroscience, interferon-α, single nucleotide polymorphism, Interferon, Internal medicine, medicine, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase, Genetic Predisposition to Disease, Allele, Promoter Regions, Genetic, genes, Molecular Biology, Alleles, Randomized Controlled Trials as Topic, Psychiatric Status Rating Scales, Polymorphism, Genetic, Depression, Interferon-alpha, Odds ratio, Hepatitis C, Chronic, Middle Aged, Center for Epidemiologic Studies Depression Scale, Recombinant Proteins, cytokines, Black or African American, Psychiatry and Mental health, 3-dioxygenase, Immunology, Female, medicine.drug |
| الوصف: | Interferon (IFN)-α treatment for infectious diseases and cancer is associated with significant depressive symptoms that can limit therapeutic efficacy. Multiple mechanisms have been implicated in IFN-α-induced depression including immune, neuroendocrine and neurotransmitter pathways. To further explore mechanisms of IFN-α-induced depression and establish associated genetic risk factors, single nucleotide polymorphisms in genes encoding proteins previously implicated in IFN-α-induced depression were explored in 2 self-reported ethnic groups, Caucasians (n=800) and African Americans (n=232), participating in a clinical trial on the impact of three pegylated IFN-α treatment regimens on sustained viral response in patients with chronic hepatitis C. Prior to treatment, all subjects were free of psychotropic medications and had a score ≤20 on the Center for Epidemiologic Studies Depression Scale (CES-D), which was used to assess depressive symptom severity throughout the study. In Caucasians, a polymorphism (rs9657182) in the promoter region of the gene encoding indoleamine-2,3-dioxygenase (IDO1) was found to be associated with moderate or severe IFN-α-induced depressive symptoms (CES-D >20) at 12 weeks of IFN-α treatment (p=0.0012, p |
| تدمد: | 1476-5578 1359-4184 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c8358e4933f24153be464cfc608374aTest https://doi.org/10.1038/mp.2011.67Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6c8358e4933f24153be464cfc608374a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14765578 13594184 |
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