A natural prodrug activation mechanism in nonribosomal peptide synthesis
| العنوان: | A natural prodrug activation mechanism in nonribosomal peptide synthesis |
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| المؤلفون: | Klaas M. Pos, Peter Grün, Helge B. Bode, Daniela Reimer, Marco Thines |
| المصدر: | Nature Chemical Biology; Vol 7 Nature Chemical Biology |
| بيانات النشر: | Springer Science and Business Media LLC, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Peptide Biosynthesis, Molecular Conformation, Stereoisomerism, 010402 general chemistry, Cleavage (embryo), 01 natural sciences, Xenorhabdus, chemistry.chemical_compound, Biosynthesis, Nonribosomal peptide, Benzopyrans, Prodrugs, Molecular Biology, chemistry.chemical_classification, Xenorhabdus nematophila, biology, 010405 organic chemistry, Cell Biology, Prodrug, biology.organism_classification, Anti-Bacterial Agents, 0104 chemical sciences, Biochemistry, chemistry, Bacteria |
| الوصف: | We have identified a new mechanism for the cleavage and activation of nonribosomally made peptides and peptide-polyketide hybrids that are apparently operational in several different bacteria. This process includes the cleavage of a precursor molecule by a membrane-bound and D-asparagine-specific peptidase, as shown here in the biosynthesis of the antibiotic xenocoumacin from Xenorhabdus nematophila. |
| تدمد: | 1552-4469 1552-4450 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ff68176e2130a3a7a8a841530150eadTest https://doi.org/10.1038/nchembio.688Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....2ff68176e2130a3a7a8a841530150ead |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15524469 15524450 |
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