Correction to: The AHR represses nucleotide excision repair and apoptosis and contributes to UV-induced skin carcinogenesis
| العنوان: | Correction to: The AHR represses nucleotide excision repair and apoptosis and contributes to UV-induced skin carcinogenesis |
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| المؤلفون: | Mana Kaveh, Melina Mescher, Thomas Haarmann-Stemmann, Siraz Shaik, Julia Tigges, Agatha Schwarz, Stephan Meller, Stephan Alexander Braun, Bernhard Homey, Jean Krutmann, Marius Pollet, Anika Bruhs, Katrin Frauenstein, Christoph F.A. Vogel, Thierry Douki, Kevin Sondenheimer, Charlotte Esser |
| المصدر: | Cell Death Differ |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Keratinocytes, Neoplasms, Radiation-Induced, Skin Neoplasms, DNA Repair, Ultraviolet Rays, Apoptosis, medicine.disease_cause, Cell Line, Mice, medicine, Animals, Humans, DNA Breaks, Double-Stranded, RNA, Small Interfering, Molecular Biology, Mice, Knockout, Mice, Hairless, business.industry, Correction, Cell Cycle Checkpoints, Cell Biology, Receptors, Aryl Hydrocarbon, Pyrimidine Dimers, Carcinoma, Squamous Cell, Cancer research, RNA Interference, Carcinogenesis, business, Cyclin-Dependent Kinase Inhibitor p27, Nucleotide excision repair |
| الوصف: | Ultraviolet B (UVB) radiation induces mutagenic DNA photoproducts, in particular cyclobutane pyrimidine dimers (CPDs), in epidermal keratinocytes (KC). To prevent skin carcinogenesis, these DNA photoproducts must be removed by nucleotide excision repair (NER) or apoptosis. Here we report that the UVB-sensitive transcription factor aryl hydrocarbon receptor (AHR) attenuates the clearance of UVB-induced CPDs in human HaCaT KC and skin from SKH-1 hairless mice. Subsequent RNA interference and inhibitor studies in KC revealed that AHR specifically suppresses global genome but not transcription-coupled NER. In further experiments, we found that the accelerated repair of CPDs in AHR-compromised KC depended on a modulation of the p27 tumor suppressor protein. Accordingly, p27 protein levels were increased in AHR-silenced KC and skin biopsies from AHR |
| تدمد: | 1476-5403 1350-9047 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff3a643948e74ca5602720fd5cd250e4Test https://doi.org/10.1038/s41418-019-0440-4Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ff3a643948e74ca5602720fd5cd250e4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14765403 13509047 |
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