The IL-23p19/EBI3 heterodimeric cytokine termed IL-39 remains a theoretical cytokine in man
| العنوان: | The IL-23p19/EBI3 heterodimeric cytokine termed IL-39 remains a theoretical cytokine in man |
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| المؤلفون: | Miriam Wittmann, Abdulla Watad, Richard Cuthbert, Dennis McGonagle, Charlie Bridgewood, Adewonuola Alase |
| المصدر: | Inflammation Research. 68:423-426 |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Pharmacology, medicine.medical_treatment, Immunology, EBI3, Biology, Acquired immune system, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Cytokine, 030220 oncology & carcinogenesis, medicine, Interleukin 23, biology.protein, Phosphorylation, Cytokine secretion, Tumor necrosis factor alpha, STAT3 |
| الوصف: | The heterodimeric IL-12 family member cytokines including, IL-12, IL-23, IL-27, and IL-35 and have multiple roles in regulating innate and adaptive immunity with crucial functions in inflammatory disorders such as psoriasis. Chain pairing promiscuity is a feature of the IL-12 family. Recently, based on murine data, a new family member, IL-39, was proposed, consisting of IL23p19 (shared with IL-23) and EBI3 (shared with IL-27 and IL-35). IL-39 has subsequently been implicated in experimental murine lupus. Given the success of IL-23p19 therapeutic targeting in diseases including psoriasis, it is of great interest to confirm the presence of IL-39 in man. Human IL-39 is yet to be either detected or expressed, which has halted research in this area. Using a disulphide-linked human chimera protein composing of IL-23p19 and EBI3 human chains, we stimulated human leukocytes, and analysed cytokine secretion and STAT3 phosphorylation. We report that this cytokine shows no activity in human cells. IL-39 chimera protein failed to induce either IL-6, IL-8, TNF, or IL-17A from leukocytes or STAT3 phosphorylation and thus, remains a ‘theoretical cytokine' in humans. |
| تدمد: | 1420-908X 1023-3830 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::dee5ab4a81dc797cb2e4a96dc4dbfddbTest https://doi.org/10.1007/s00011-019-01235-xTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........dee5ab4a81dc797cb2e4a96dc4dbfddb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1420908X 10233830 |
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