المؤلفون: Guddeti, Rohith Kumar, Pacharla, Himavani, Yellapu, Nanda Kumar, Karyala, Prashanthi, Pakala, Suresh B.

المصدر: Medical Oncology ; volume 40, issue 3 ; ISSN 1559-131X

مصطلحات موضوعية: Cancer Research, Oncology, Hematology, General Medicine

الإتاحة: https://doi.org/10.1007/s12032-023-01974-2Test

المؤلفون: Vattem, Chaitanya, Pakala, Suresh B

المصدر: Journal of Biosciences ; volume 47, issue 2 ; ISSN 0973-7138

مصطلحات موضوعية: General Agricultural and Biological Sciences, General Biochemistry, Genetics and Molecular Biology, General Medicine

الإتاحة: https://doi.org/10.1007/s12038-022-00263-wTest

المؤلفون: Saroha, Himanshu Singh, Kumar Guddeti, Rohith, Jacob, Jasmine P., Kumar Pulukuri, Kiran, Karyala, Prashanthi, Pakala, Suresh B.

المصدر: Medical Oncology ; volume 39, issue 9 ; ISSN 1559-131X

مصطلحات موضوعية: Cancer Research, Oncology, Hematology, General Medicine

الإتاحة: https://doi.org/10.1007/s12032-022-01728-6Test

المؤلفون: Guddeti, Rohith Kumar, Chutani, Namita, Pakala, Suresh B.

المصدر: Biophysical Reviews ; volume 13, issue 4, page 507-514 ; ISSN 1867-2450 1867-2469

مصطلحات موضوعية: Molecular Biology, Structural Biology, Biophysics

الإتاحة: https://doi.org/10.1007/s12551-021-00812-xTest

المؤلفون: Li, Da-Qiang, Pakala, Suresh B., Reddy, Sirigiri Divijendra Natha, Peng, Shaohua, Balasenthil, Seetharaman, Deng, Chu-Xia, Lee, Cheng Chi, Rea, Michael A., Kumar, Rakesh

المصدر: Nature Communications ; volume 4, issue 1 ; ISSN 2041-1723

مصطلحات موضوعية: General Physics and Astronomy, General Biochemistry, Genetics and Molecular Biology, General Chemistry, Multidisciplinary

الإتاحة: https://doi.org/10.1038/ncomms3545Test
https://www.nature.com/articles/ncomms3545.pdfTest
https://www.nature.com/articles/ncomms3545Test

المؤلفون: Eswaran, Jeyanthy, Cyanam, Dinesh, Mudvari, Prakriti, Reddy, Sirigiri Divijendra Natha, Pakala, Suresh B., Nair, Sujit S., Florea, Liliana, Fuqua, Suzanne A. W., Godbole, Sucheta, Kumar, Rakesh

المصدر: Scientific Reports ; volume 2, issue 1 ; ISSN 2045-2322

مصطلحات موضوعية: Multidisciplinary

الإتاحة: https://doi.org/10.1038/srep00264Test
https://www.nature.com/articles/srep00264Test
https://www.nature.com/articles/srep00264.pdfTest

المؤلفون: Ohshiro, Kazufumi, Rayala, Suresh K, Wigerup, Caroline, Pakala, Suresh B, Natha, Reddy S Divijendra, Gururaj, Anupama E, Molli, Poonam R, Månsson, Sofie Svensson, Ramezani, Ali, Hawley, Robert G, Landberg, Goran, Lee, Norman H, Kumar, Rakesh

المصدر: EMBO reports ; volume 11, issue 9, page 691-697 ; ISSN 1469-221X 1469-3178

مصطلحات موضوعية: Genetics, Molecular Biology, Biochemistry

الوصف: High expression of metastasis‐associated protein 1 co‐regulator (MTA1), a component of the nuclear remodelling and histone deacetylase complex, has been associated with human tumours. However, the precise role of MTA1 in tumorigenesis remains unknown. In this study, we show that induced levels of MTA1 are sufficient to transform Rat1 fibroblasts and that the transforming potential of MTA1 is dependent on its acetylation at Lys626. Underlying mechanisms of MTA1‐mediated transformation include activation of the Ras–Raf pathway by MTA1 but not by acetylation‐inactive MTA1; this was due to the repression of G α i 2 transcription, which negatively influences Ras activation. We observed that acetylated MTA1–histone deacetylase (HDAC) interaction was required for the recruitment of the MTA1–HDAC complex to the G α i 2 regulatory element and consequently for the repression of G α i 2 transcription and expression leading to activation of the Ras–Raf pathway. The findings presented in this study provide for the first time—to the best of our knowledge—evidence of acetylation‐dependent oncogenic activity of a cancer‐relevant gene product.

الإتاحة: https://doi.org/10.1038/embor.2010.99Test

المؤلفون: Pakala, Suresh B., Gorla, Purushotham, Pinjari, Aleem Basha, Krovidi, Ravi Kumar, Baru, Rajasekhar, Yanamandra, Mahesh, Merrick, Mike, Siddavattam, Dayananda

المصدر: Applied Microbiology and Biotechnology ; volume 73, issue 6, page 1452-1462 ; ISSN 0175-7598 1432-0614

مصطلحات موضوعية: Applied Microbiology and Biotechnology, General Medicine, Biotechnology

الإتاحة: https://doi.org/10.1007/s00253-006-0595-zTest