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1دورية أكاديمية
المؤلفون: Lax, Gianluca, Nardone, Roberto, Russo, Antonia
المساهمون: Regione Calabria, Università degli Studi Mediterranea di Reggio Calabria
المصدر: Multimedia Tools and Applications ; ISSN 1573-7721
مصطلحات موضوعية: Computer Networks and Communications, Hardware and Architecture, Media Technology, Software
الوصف: The facilitation of sharing and exchanging patients’ health records is a paramount opportunity in e-health, enabling healthcare providers to garner a comprehensive and clear perspective of patients’ medical histories without necessitating direct inquiries. Besides this great advantage, it introduces substantial issues on security and privacy, mainly related to unauthorized access to e-health records when different healthcare service providers maintain records. In this paper, we deal with this problem and propose using the blockchain technology (1) to obfuscate the linkage between patients’ identities and their e-health records and (2) to grant access to e-health records exclusively to entities authorized by patients themselves. Key outcomes include using a digital identity based on the Electronic Identification, Authentication, and Trust Services Regulation (eIDAS) to control access to these records, and a concrete implementation by adopting the Ethereum blockchain. Our solution relies on using a public blockchain, which is an improvement for the state of the art, in which only private or consortium blockchains have been proposed. The resulting solution has been analyzed, and the effectiveness and affordability of the proposal have been shown.
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2دورية أكاديمية
المؤلفون: Kanoni, Stavroula, Graham, Sarah E, Wang, Yuxuan, Surakka, Ida, Ramdas, Shweta, Zhu, Xiang, Clarke, Shoa L, Bhatti, Konain Fatima, Vedantam, Sailaja, Winkler, Thomas W, Locke, Adam E, Marouli, Eirini, Zajac, Greg JM, Wu, Kuan-Han H, Ntalla, Ioanna, Hui, Qin, Klarin, Derek, Hilliard, Austin T, Wang, Zeyuan, Xue, Chao, Thorleifsson, Gudmar, Helgadottir, Anna, Gudbjartsson, Daniel F, Holm, Hilma, Olafsson, Isleifur, Hwang, Mi Yeong, Han, Sohee, Akiyama, Masato, Sakaue, Saori, Terao, Chikashi, Kanai, Masahiro, Zhou, Wei, Brumpton, Ben M, Rasheed, Humaira, Havulinna, Aki S, Veturi, Yogasudha, Pacheco, Jennifer Allen, Rosenthal, Elisabeth A, Lingren, Todd, Feng, QiPing, Kullo, Iftikhar J, Narita, Akira, Takayama, Jun, Martin, Hilary C, Hunt, Karen A, Trivedi, Bhavi, Haessler, Jeffrey, Giulianini, Franco, Bradford, Yuki, Miller, Jason E, Campbell, Archie, Lin, Kuang, Millwood, Iona Y, Rasheed, Asif, Hindy, George, Faul, Jessica D, Zhao, Wei, Weir, David R, Turman, Constance, Huang, Hongyan, Graff, Mariaelisa, Choudhury, Ananyo, Sengupta, Dhriti, Mahajan, Anubha, Brown, Michael R, Zhang, Weihua, Yu, Ketian, Schmidt, Ellen M, Pandit, Anita, Gustafsson, Stefan, Yin, Xianyong, Luan, Jian'an, Zhao, Jing-Hua, Matsuda, Fumihiko, Jang, Hye-Mi, Yoon, Kyungheon, Medina-Gomez, Carolina, Pitsillides, Achilleas, Hottenga, Jouke Jan, Wood, Andrew R, Ji, Yingji, Gao, Zishan, Haworth, Simon, Yousri, Noha A, Mitchell, Ruth E, Chai, Jin Fang, Aadahl, Mette, Bjerregaard, Anne A, Yao, Jie, Manichaikul, Ani, Hwu, Chii-Min, Hung, Yi-Jen, Warren, Helen R, Ramirez, Julia, Bork-Jensen, Jette, Kårhus, Line L, Goel, Anuj, Sabater-Lleal, Maria, Noordam, Raymond, Mauro, Pala, Matteo, Floris, McDaid, Aaron F, Marques-Vidal, Pedro, Wielscher, Matthias, Trompet, Stella, Sattar, Naveed, Møllehave, Line T, Munz, Matthias, Zeng, Lingyao, Huang, Jianfeng, Yang, Bin, Poveda, Alaitz, Kurbasic, Azra, Lamina, Claudia, Forer, Lukas, Scholz, Markus, Galesloot, Tessel E, Bradfield, Jonathan P, Ruotsalainen, Sanni E, Daw, EWarwick, Zmuda, Joseph M, Mitchell, Jonathan S, Fuchsberger, Christian, Christensen, Henry, Brody, Jennifer A, Vazquez-Moreno, Miguel, Feitosa, Mary F, Wojczynski, Mary K, Wang, Zhe, Preuss, Michael H, Mangino, Massimo, Christofidou, Paraskevi, Verweij, Niek, Benjamins, Jan W, Engmann, Jorgen, Tsao, Noah L, Verma, Anurag, Slieker, Roderick C, Lo, Ken Sin, Zilhao, Nuno R, Le, Phuong, Kleber, Marcus E, Delgado, Graciela E, Huo, Shaofeng, Ikeda, Daisuke D, Iha, Hiroyuki, Yang, Jian, Liu, Jun, Demirkan, Ayşe, Leonard, Hampton L, Marten, Jonathan, Frank, Mirjam, Schmidt, Börge, Smyth, Laura J, Cañadas-Garre, Marisa, Wang, Chaolong, Nakatochi, Masahiro, Wong, Andrew, Hutri-Kähönen, Nina, Sim, Xueling, Xia, Rui, Huerta-Chagoya, Alicia, Fernandez-Lopez, Juan Carlos, Lyssenko, Valeriya, Nongmaithem, Suraj S, Bayyana, Swati, Stringham, Heather M, Irvin, Marguerite R, Oldmeadow, Christopher, Kim, Han-Na, Ryu, Seungho, Timmers, Paul RHJ, Arbeeva, Liubov, Dorajoo, Rajkumar, Lange, Leslie A, Prasad, Gauri, Lorés-Motta, Laura, Pauper, Marc, Long, Jirong, Li, Xiaohui, Theusch, Elizabeth, Takeuchi, Fumihiko, Spracklen, Cassandra N, Loukola, Anu, Bollepalli, Sailalitha, Warner, Sophie C, Wang, Ya Xing, Wei, Wen B, Nutile, Teresa, Ruggiero, Daniela, Sung, Yun Ju, Chen, Shufeng, Liu, Fangchao, Yang, Jingyun, Kentistou, Katherine A, Banas, Bernhard, Nardone, Giuseppe Giovanni, Meidtner, Karina, Bielak, Lawrence F, Smith, Jennifer A, Hebbar, Prashantha, Farmaki, Aliki-Eleni, Hofer, Edith, Lin, Maoxuan, Concas, Maria Pina, Vaccargiu, Simona, van der Most, Peter J, Pitkänen, Niina, Cade, Brian E, van der Laan, Sander W, Chitrala, Kumaraswamy Naidu, Weiss, Stefan, Bentley, Amy R, Doumatey, Ayo P, Adeyemo, Adebowale A, Lee, Jong Young, Petersen, Eva RB, Nielsen, Aneta A, Choi, Hyeok Sun, Nethander, Maria, Freitag-Wolf, Sandra, Southam, Lorraine, Rayner, Nigel W, Wang, Carol A, Lin, Shih-Yi, Wang, Jun-Sing, Couture, Christian, Lyytikäinen, Leo-Pekka, Nikus, Kjell, Cuellar-Partida, Gabriel, Vestergaard, Henrik, Hidalgo, Bertha, Giannakopoulou, Olga, Cai, Qiuyin, Obura, Morgan O, van Setten, Jessica, Li, Xiaoyin, Liang, Jingjing, Tang, Hua, Terzikhan, Natalie, Shin, Jae Hun, Jackson, Rebecca D, Reiner, Alexander P, Martin, Lisa Warsinger, Chen, Zhengming, Li, Liming, Kawaguchi, Takahisa, Thiery, Joachim, Bis, Joshua C, Launer, Lenore J, Li, Huaixing, Nalls, Mike A, Raitakari, Olli T, Ichihara, Sahoko, Wild, Sarah H, Nelson, Christopher P, Campbell, Harry, Jäger, Susanne, Nabika, Toru, Al-Mulla, Fahd, Niinikoski, Harri, Braund, Peter S, Kolcic, Ivana, Kovacs, Peter, Giardoglou, Tota, Katsuya, Tomohiro, de Kleijn, Dominique, de Borst, Gert J, Kim, Eung Kweon, Adams, Hieab HH, Ikram, M Arfan, Zhu, Xiaofeng, Asselbergs, Folkert W, Kraaijeveld, Adriaan O, Beulens, Joline WJ, Shu, Xiao-Ou, Rallidis, Loukianos S, Pedersen, Oluf, Hansen, Torben, Mitchell, Paul, Hewitt, Alex W, Kähönen, Mika, Pérusse, Louis, Bouchard, Claude, Tönjes, Anke, Chen, Yii-Der Ida, Pennell, Craig E, Mori, Trevor A, Lieb, Wolfgang, Franke, Andre, Ohlsson, Claes, Mellström, Dan, Cho, Yoon Shin, Lee, Hyejin, Yuan, Jian-Min, Koh, Woon-Puay, Rhee, Sang Youl, Woo, Jeong-Taek, Heid, Iris M, Stark, Klaus J, Zimmermann, Martina E, Völzke, Henry, Homuth, Georg, Evans, Michele K, Zonderman, Alan B, Polasek, Ozren, Pasterkamp, Gerard, Hoefer, Imo E, Redline, Susan, Pahkala, Katja, Oldehinkel, Albertine J, Snieder, Harold, Biino, Ginevra, Schmidt, Reinhold, Schmidt, Helena, Bandinelli, Stefania, Dedoussis, George, Thanaraj, Thangavel Alphonse, Kardia, Sharon LR, Peyser, Patricia A, Kato, Norihiro, Schulze, Matthias B, Girotto, Giorgia, Böger, Carsten A, Jung, Bettina, Joshi, Peter K, Bennett, David A, De Jager, Philip L, Lu, Xiangfeng, Mamakou, Vasiliki, Brown, Morris, Caulfield, Mark J, Munroe, Patricia B, Guo, Xiuqing, Ciullo, Marina, Jonas, Jost B, Samani, Nilesh J, Kaprio, Jaakko, Pajukanta, Päivi, Tusié-Luna, Teresa, Aguilar-Salinas, Carlos A, Adair, Linda S, Bechayda, Sonny Augustin, de Silva, H Janaka, Wickremasinghe, Ananda R, Krauss, Ronald M, Wu, Jer-Yuarn, Zheng, Wei, Hollander, Anneke Iden, Bharadwaj, Dwaipayan, Correa, Adolfo, Wilson, James G, Lind, Lars, Heng, Chew-Kiat, Nelson, Amanda E, Golightly, Yvonne M, Wilson, James F, Penninx, Brenda, Kim, Hyung-Lae, Attia, John, Scott, Rodney J, Rao, DC, Arnett, Donna K, Hunt, Steven C, Walker, Mark, Koistinen, Heikki A, Chandak, Giriraj R, Mercader, Josep M, Costanzo, Maria C, Jang, Dongkeun, Burtt, Noël P, Villalpando, Clicerio Gonzalez, Orozco, Lorena, Fornage, Myriam, Tai, EShyong, van Dam, Rob M, Lehtimäki, Terho, Chaturvedi, Nish, Yokota, Mitsuhiro, Liu, Jianjun, Reilly, Dermot F, McKnight, Amy Jayne, Kee, Frank, Jöckel, Karl-Heinz, McCarthy, Mark I, Palmer, Colin NA, Vitart, Veronique, Hayward, Caroline, Simonsick, Eleanor, van Duijn, Cornelia M, Jin, Zi-Bing, Qu, Jia, Hishigaki, Haretsugu, Lin, Xu, März, Winfried, Gudnason, Vilmundur, Tardif, Jean-Claude, Lettre, Guillaume, Hart, Leen M 't, Elders, Petra JM, Damrauer, Scott M, Kumari, Meena, Kivimaki, Mika, van der Harst, Pim, Spector, Tim D, Loos, Ruth JF, Province, Michael A, Parra, Esteban J, Cruz, Miguel, Psaty, Bruce M, Brandslund, Ivan, Pramstaller, Peter P, Rotimi, Charles N, Christensen, Kaare, Ripatti, Samuli, Widén, Elisabeth, Hakonarson, Hakon, Grant, Struan FA, Kiemeney, Lambertus ALM, de Graaf, Jacqueline, Loeffler, Markus, Kronenberg, Florian, Gu, Dongfeng, Erdmann, Jeanette, Schunkert, Heribert, Franks, Paul W, Linneberg, Allan, Jukema, J Wouter, Khera, Amit V, Männikkö, Minna, Jarvelin, Marjo-Riitta, Kutalik, Zoltan, Francesco, Cucca, Mook-Kanamori, Dennis O, van Dijk, Ko Willems, Watkins, Hugh, Strachan, David P, Grarup, Niels, Sever, Peter, Poulter, Neil, Chuang, Lee-Ming, Rotter, Jerome I, Dantoft, Thomas M, Karpe, Fredrik, Neville, Matt J, Timpson, Nicholas J, Cheng, Ching-Yu, Wong, Tien-Yin, Khor, Chiea Chuen, Li, Hengtong, Sabanayagam, Charumathi, Peters, Annette, Gieger, Christian, Hattersley, Andrew T, Pedersen, Nancy L, Magnusson, Patrik KE, Boomsma, Dorret I, Willemsen, Allegonda HM, Cupples, LAdrienne, van Meurs, Joyce BJ, Ghanbari, Mohsen, Gordon-Larsen, Penny, Huang, Wei, Kim, Young Jin, Tabara, Yasuharu, Wareham, Nicholas J, Langenberg, Claudia, Zeggini, Eleftheria, Kuusisto, Johanna, Laakso, Markku, Ingelsson, Erik, Abecasis, Goncalo, Chambers, John C, Kooner, Jaspal S, de Vries, Paul S, Morrison, Alanna C, Hazelhurst, Scott, Ramsay, Michèle, North, Kari E, Daviglus, Martha, Kraft, Peter, Martin, Nicholas G, Whitfield, John B, Abbas, Shahid, Saleheen, Danish, Walters, Robin G, Holmes, Michael V, Black, Corri, Smith, Blair H, Baras, Aris, Justice, Anne E, Buring, Julie E, Ridker, Paul M, Chasman, Daniel I, Kooperberg, Charles, Tamiya, Gen, Yamamoto, Masayuki, van Heel, David A, Trembath, Richard C, Wei, Wei-Qi, Jarvik, Gail P, Namjou, Bahram, Hayes, M Geoffrey, Ritchie, Marylyn D, Jousilahti, Pekka, Salomaa, Veikko, Hveem, Kristian, Åsvold, Bjørn Olav, Kubo, Michiaki, Kamatani, Yoichiro, Okada, Yukinori, Murakami, Yoshinori, Kim, Bong-Jo, Thorsteinsdottir, Unnur, Stefansson, Kari, Zhang, Jifeng, Chen, YEugene, Ho, Yuk-Lam, Lynch, Julie A, Rader, Daniel J, Tsao, Philip S, Chang, Kyong-Mi, Cho, Kelly, O'Donnell, Christopher J, Gaziano, John M, Wilson, Peter WF, Frayling, Timothy M, Hirschhorn, Joel N, Kathiresan, Sekar, Mohlke, Karen L, Sun, Yan V, Morris, Andrew P, Boehnke, Michael, Brown, Christopher D, Natarajan, Pradeep, Deloukas, Panos, Willer, Cristen J, Assimes, Themistocles L, Peloso, Gina M
المصدر: essn: 1474-760X ; nlmid: 100960660
مصطلحات موضوعية: Cholesterol, GWAS, Genetics, Genome-wide association study, Lipids, Humans, Genetic Predisposition to Disease, Sex Characteristics, Phenotype, Polymorphism, Single Nucleotide, Genetic Pleiotropy
الوصف: BACKGROUND: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. RESULTS: To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3-5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism. CONCLUSIONS: Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.
وصف الملف: application/pdf
الإتاحة: https://doi.org/10.17863/CAM.93301Test
https://www.repository.cam.ac.uk/handle/1810/345879Test -
3دورية أكاديمية
المؤلفون: Mishra, A, Zhou, B, Rodriguez-Martinez, A, Bixby, H, Singleton, RK, Carrillo-Larco, RM, Sheffer, KE, Paciorek, CJ, Bennett, JE, Lhoste, V, Iurilli, MLC, Di Cesare, M, Bentham, J, Phelps, NH, Sophiea, MK, Stevens, GA, Danaei, G, Cowan, MJ, Savin, S, Riley, LM, Gregg, EW, Aekplakorn, W, Ahmad, NA, Baker, JL, Chirita-Emandi, A, Farzadfar, F, Fink, G, Heinen, M, Ikeda, N, Kengne, AP, Khang, Y-H, Laatikainen, T, Laxmaiah, A, Ma, J, Monroy-Valle, M, Mridha, MK, Padez, CP, Reynolds, A, Sorić, M, Starc, G, Wirth, JP, Abarca-Gómez, L, Abdeen, ZA, Abdrakhmanova, S, Ghaffar, SA, Abdul Rahim, HF, Abdurrahmonova, Z, Abu-Rmeileh, NM, Garba, JA, Acosta-Cazares, B, Adam, I, Adamczyk, M, Adams, RJ, Adu-Afarwuah, S, Afsana, K, Afzal, S, Agbor, VN, Agdeppa, IA, Aghazadeh-Attari, J, Aguenaou, H, Aguilar-Salinas, CA, Agyemang, C, Ahmad, MH, Ahmadi, A, Ahmadi, N, Ahmed, I, Ahmed, SH, Ahrens, W, Aitmurzaeva, G, Ajlouni, K, Al-Hazzaa, HM, Al-Lahou, B, Al-Raddadi, R, Al Hourani, HM, Al Qaoud, NM, Alarouj, M, AlBuhairan, F, AlDhukair, S, Aldwairji, MA, Alexius, S, Ali, MM, Alkandari, A, Alkerwi, A, Alkhatib, BM, Allin, K, Alvarez-Pedrerol, M, Aly, E, Amarapurkar, DN, Etxezarreta, PA, Amoah, J, Amougou, N, Amouyel, P, Andersen, LB, Anderssen, SA, Androutsos, O, Ängquist, L, Anjana, RM, Ansari-Moghaddam, A, Anufrieva, E, Aounallah-Skhiri, H, Araújo, J, Ariansen, I, Aris, T, Arku, RE, Arlappa, N, Aryal, KK, Aseffa, N, Aspelund, T, Assah, FK, Assembekov, B, Assunção, MCF, Aung, MS, Auvinen, J, Avdičová, M, Avi, S, Azevedo, A, Azimi-Nezhad, M, Azizi, F, Azmin, M, Babu, BV, Jørgensen, MB, Baharudin, A, Bahijri, S, Bakacs, M, Balakrishna, N, Balanova, Y, Bamoshmoosh, M, Banach, M, Banegas, JR, Baran, J, Baran, R, Barbagallo, CM, Filho, VB, Barceló, A, Baretić, M, Barkat, A, Barnoya, J, Barrera, L, Barreto, M, Barros, AJD, Barros, MVG, Bartosiewicz, A, Basit, A, Bastos, JLD, Bata, I, Batieha, AM, Batista, AP, Batista, RL, Battakova, Z, Baur, LA, Bayauli, PM, Beaglehole, R, Bel-Serrat, S, Belavendra, A, Ben Romdhane, H, Benedics, J, Benet, M, Rolandi, GEB, Bere, E, Bergh, IH, Berhane, Y, Berkinbayev, S, Bernabe-Ortiz, A, Bernotiene, G, Carrasola, XB, Bettiol, H, Beutel, ME, Beybey, AF, Bezerra, J, Bhagyalaxmi, A, Bharadwaj, S, Bhargava, SK, Bi, H, Bi, Y, Bia, D, Biasch, K, Lele, ECB, Bikbov, MM, Bista, B, Bjelica, DJ, Bjerregaard, AA, Bjerregaard, P, Bjertness, E, Bjertness, MB, Björkelund, C, Bloch, KV, Blokstra, A, Magnazu, MB, Bo, S, Bobak, M, Boddy, LM, Boehm, BO, Boer, JMA, Boggia, JG, Bogova, E, Boissonnet, CP, Bojesen, SE, Bonaccio, M, Bongard, V, Bonilla-Vargas, A, Bopp, M, Borghs, H, Bovet, P, Boymatova, K, Braeckevelt, L, Braeckman, L, Bragt, MCE, Brajkovich, I, Branca, F, Breckenkamp, J, Breda, J, Brenner, H, Brewster, LM, Brian, GR, Briceño, Y, Brinduse, L, Brito, M, Brophy, S, Brug, J, Bruno, G, Bugge, A, Buntinx, F, Buoncristiano, M, Burazeri, G, Burns, C, de León, AC, Cacciottolo, J, Cai, H, Caixeta, RB, Cama, T, Cameron, C, Camolas, J, Can, G, Cândido, APC, Cañete, F, Capanzana, MV, Čapková, N, Capuano, E, Capuano, R, Capuano, V, Cardol, M, Cardoso, VC, Carlsson, AC, Carmuega, E, Carvalho, J, Casajús, JA, Casanueva, FF, Casas, M, Celikcan, E, Censi, L, Cervantes‐Loaiza, M, Cesar, JA, Chamukuttan, S, Chan, A, Chan, Q, Chaturvedi, HK, Chaturvedi, N, Rahim, NCA, Chee, ML, Chen, C-J, Chen, F, Chen, H, Chen, S, Chen, Z, Cheng, C-Y, Cheng, YJ, Cheraghian, B, Chetrit, A, Chikova-Iscener, E, Chinapaw, MJM, Chinnock, A, Chiolero, A, Chiou, S-T, Chirlaque, M-D, Cho, B, Christensen, K, Christofaro, DG, Chudek, J, Cifkova, R, Cilia, M, Cinteza, E, Cirillo, M, Claessens, F, Clarke, J, Clays, E, Cohen, E, Compañ-Gabucio, L-M, Concin, H, Confortin, SC, Cooper, C, Coppinger, TC, Corpeleijn, E, Cortés, LY, Costanzo, S, Cottel, D, Cowell, C, Craig, CL, Crampin, AC, Cross, AJ, Crujeiras, AB, Cruz, JJ, Csányi, T, Csilla, S, Cucu, AM, Cui, L, Cureau, FV, Cuschieri, S, Czenczek-Lewandowska, E, D’Arrigo, G, d’Orsi, E, Dacica, L, Dallongeville, J, Damasceno, A, Damsgaard, CT, Dankner, R, Dantoft, TM, Dasgupta, P, Dastgiri, S, Dauchet, L, Davletov, K, de Assis, MAA, De Backer, G, De Bacquer, D, De Curtis, A, de Fragas Hinnig, P, de Gaetano, G, De Henauw, S, De Miguel-Etayo, P, de Oliveira, PD, De Ridder, D, De Ridder, K, de Rooij, SR, De Smedt, D, Deepa, M, Deev, AD, DeGennaro, V, Delisle, H, Delpeuch, F, Demarest, S, Dennison, E, Dereń, K, Deschamps, V, Dhimal, M, Di Castelnuovo, A, Dias-da-Costa, JS, Díaz-Sánchez, ME, Diaz, A, Fernández, PD, Ripollés, MPD, Dika, Z, Djalalinia, S, Djordjic, V, Do, HTP, Dobson, AJ, Dominguez, L, Donati, MB, Donfrancesco, C, Dong, G, Dong, Y, Donoso, SP, Döring, A, Dorobantu, M, Dorosty, AR, Doua, K, Dragano, N, Drygas, W, Duan, JL, Duante, CA, Duboz, P, Duleva, VL, Dulskiene, V, Dumith, SC, Dushpanova, A, Dyussupova, A, Dzerve, V, Dziankowska-Zaborszczyk, E, Echeverría, G, Eddie, R, Eftekhar, E, Egbagbe, EE, Eggertsen, R, Eghtesad, S, Eiben, G, Ekelund, U, El-Khateeb, M, El Ammari, L, El Ati, J, 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مصطلحات موضوعية: RC1200 Sports Medicine
الوصف:
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العلاقة: https://researchonline.ljmu.ac.uk/id/eprint/19198/1/Diminishing%20benefits%20of%20urban%20living%20for%20children%20and%20adolescents%20growth%20adn%20development.pdfTest; Mishra, A, Zhou, B, Rodriguez-Martinez, A, Bixby, H, Singleton, RK, Carrillo-Larco, RM, Sheffer, KE, Paciorek, CJ, Bennett, JE, Lhoste, V, Iurilli, MLC, Di Cesare, M, Bentham, J, Phelps, NH, Sophiea, MK, Stevens, GA, Danaei, G, Cowan, MJ, Savin, S, Riley, LM, Gregg, EW, Aekplakorn, W, Ahmad, NA, Baker, JL, Chirita-Emandi, A, Farzadfar, F, Fink, G, Heinen, M, Ikeda, N, Kengne, AP, Khang, Y-H, Laatikainen, T, Laxmaiah, A, Ma, J, Monroy-Valle, M, Mridha, MK, Padez, CP, Reynolds, A, Sorić, M, Starc, G, Wirth, JP, Abarca-Gómez, L, Abdeen, ZA, Abdrakhmanova, S, Ghaffar, SA, Abdul Rahim, HF, Abdurrahmonova, Z, Abu-Rmeileh, NM, Garba, JA, Acosta-Cazares, B, Adam, I, Adamczyk, M, Adams, RJ, Adu-Afarwuah, S, Afsana, K, Afzal, S, Agbor, VN, Agdeppa, IA, Aghazadeh-Attari, J, Aguenaou, H, Aguilar-Salinas, CA, Agyemang, 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M, Bhutta, ZA, Black, RE and Ezzati, M (2023) Diminishing benefits of urban living for children and adolescents’ growth and development. Nature, 615. pp. 874-883. ISSN 0028-0836
الإتاحة: https://doi.org/10.1038/s41586-023-05772-8Test
http://researchonline.ljmu.ac.uk/id/eprint/19198Test/
https://researchonline.ljmu.ac.uk/id/eprint/19198/1/Diminishing%20benefits%20of%20urban%20living%20for%20children%20and%20adolescents%20growth%20adn%20development.pdfTest -
4دورية أكاديمية
المساهمون: Horizon 2020 Framework Programme, Università Parthenope di Napoli
المصدر: Environment Systems and Decisions ; volume 43, issue 4, page 708-720 ; ISSN 2194-5403 2194-5411
مصطلحات موضوعية: General Environmental Science
الوصف: Resilience improvement of complex internets of utility systems is still an open issue for the current research. Proposed solutions fail to implement an integrated approach to detection, mitigation, and reaction which is able to face both well-known and new, previously unknown cyber-attacks (in particular distributed ones, which constitute one of the most serious and still unresolved threat scenarios affecting networked systems). In this work, we present the conceptual architecture of a novel multi-layer distributed Intrusion Detection and Reaction System based on the Autonomic Communication paradigm. The architecture relies on a self-organizing cooperative overlay network of complementary components that are dynamically and autonomously adapted to face distributed cyberattacks against Industrial Control Systems. The proposed architecture aims at being a guideline for experts and practitioners to address the well-known problem of distributed nature of new types of cyber-attacks, by implementing mechanisms to orchestrate available resources for effective detection and remediation dynamically. A distributed flow monitoring system provides input data to cooperative intrusion detection agents, which allow correlating information from heterogeneous feeds to improve the identification of attacks originating from both the inside and the outside of the monitored network and to support customizable remediation mechanisms.
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5دورية أكاديمية
المؤلفون: Fanizzi, Annarita, Fadda, Federico, Comes, Maria Colomba, Bove, Samantha, Catino, Annamaria, Di Benedetto, Erika, Milella, Angelo, Montrone, Michele, Nardone, Annalisa, Soranno, Clara, Rizzo, Alessandro, Guven, Deniz Can, Galetta, Domenico, Massafra, Raffaella
المصدر: Scientific Reports ; volume 13, issue 1 ; ISSN 2045-2322
مصطلحات موضوعية: Multidisciplinary
الوصف: Non-Small cell lung cancer (NSCLC) is one of the most dangerous cancers, with 85% of all new lung cancer diagnoses and a 30–55% of recurrence rate after surgery. Thus, an accurate prediction of recurrence risk in NSCLC patients during diagnosis could be essential to drive targeted therapies preventing either overtreatment or undertreatment of cancer patients. The radiomic analysis of CT images has already shown great potential in solving this task; specifically, Convolutional Neural Networks (CNNs) have already been proposed providing good performances. Recently, Vision Transformers (ViTs) have been introduced, reaching comparable and even better performances than traditional CNNs in image classification. The aim of the proposed paper was to compare the performances of different state-of-the-art deep learning algorithms to predict cancer recurrence in NSCLC patients. In this work, using a public database of 144 patients, we implemented a transfer learning approach, involving different Transformers architectures like pre-trained ViTs, pre-trained Pyramid Vision Transformers, and pre-trained Swin Transformers to predict the recurrence of NSCLC patients from CT images, comparing their performances with state-of-the-art CNNs. Although, the best performances in this study are reached via CNNs with AUC, Accuracy, Sensitivity, Specificity, and Precision equal to 0.91, 0.89, 0.85, 0.90, and 0.78, respectively, Transformer architectures reach comparable ones with AUC, Accuracy, Sensitivity, Specificity, and Precision equal to 0.90, 0.86, 0.81, 0.89, and 0.75, respectively. Based on our preliminary experimental results, it appears that Transformers architectures do not add improvements in terms of predictive performance to the addressed problem.
الإتاحة: https://doi.org/10.1038/s41598-023-48004-9Test
https://www.nature.com/articles/s41598-023-48004-9.pdfTest
https://www.nature.com/articles/s41598-023-48004-9Test -
6دورية أكاديمية
المؤلفون: Giustini, Marco, Luzi, Ilaria, Spinelli, Angela, Andreozzi, Silvia, Bucciarelli, Mauro, Buoncristiano, Marta, Nardone, Paola, Ciardullo, Silvia, Giustin, Marco, Giusti, Angela, Cattaneo, Chiara, Gentile, Amalia Egle, Zambri, Francesca, Palermo, Vittorio, Nolfi, Annachiara Di, Tambascia, Gabriella, Colleluori, Claudia, Di Giacomo, Manuela, Ranalli, Ercole, Mininni, Mariangela, Cernuzio, Antonella, Lucia, Francesco, Mignuoli, Anna Domenica, Mortati, Filomena, Mazzarella, Gianfranco, Angelini, Paola, Broccoli, Serena, Fridel, Marina, Pani, Paola, Carletti, Claudia, Concina, Federica, Ronfani, Luca, Biscaglia, Lilia, Cairella, Giulia, Pancallo, Maria Teresa, Pozzo, Laura, Sticchi, Camilla, Varlese, Federica, Celata, Corrado, Leoni, Olivia, Crottogini, Lucia, Lobascio, Claudia, Gelmi, Giusi
المساهمون: Istituto Superiore di Sanità
المصدر: Italian Journal of Pediatrics ; volume 49, issue 1 ; ISSN 1824-7288
مصطلحات موضوعية: General Medicine
الوصف: Background While existing research has explored changes in health behaviours among adults and adolescents due to the COVID-19 outbreak, the impact of quarantine on young children’s well-being is still less clear. Moreover, most of the published studies were carried out on small and non-representative samples. The aim of the EpaS-ISS study was to describe the impact of the COVID-19 pandemic on the habits and behaviours of a representative sample of school children aged mainly 8–9 years and their families living in Italy, exploring the changes in children’s well-being during the COVID-19 pandemic compared to the immediately preceding time period. Methods Data were collected using a web questionnaire. The target population was parents of children attending third-grade primary schools and living in Italy. A cluster sample design was adopted. A Well-Being Score (WBS) was calculated by summing the scores from 10 items concerning the children’s well-being. Associations between WBS and socio-demographic variables and other variables were analysed. Results A total of 4863 families participated. The children’s WBS decreased during COVID-19 (median value from 31 to 25; p = 0.000). The most statistically significant variables related to a worsening children’s WBS were: time of school closure, female gender, living in a house with only a small and unliveable outdoor area, high parents’ educational level and worsening financial situation. Conclusions According to parents ' perception, changes in daily routine during COVID-19 negatively affected children’s well-being. This study has identified some personal and contextual variables associated with the worsening of children’s WBS, which should be considered in case of similar events.
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7دورية أكاديمية
المؤلفون: Nardone, Valerio, Romeo, Caterina, D’Ippolito, Emma, Pastina, Pierpaolo, D’Apolito, Maria, Pirtoli, Luigi, Caraglia, Michele, Mutti, Luciano, Bianco, Giovanna, Falzea, Antonella Consuelo, Giannicola, Rocco, Giordano, Antonio, Tagliaferri, Pierosandro, Vinciguerra, Claudia, Desideri, Isacco, Loi, Mauro, Reginelli, Alfonso, Cappabianca, Salvatore, Tassone, Pierfrancesco, Correale, Pierpaolo
المساهمون: Università degli Studi della Campania Luigi Vanvitelli
المصدر: La radiologia medica ; volume 128, issue 3, page 316-329 ; ISSN 1826-6983
مصطلحات موضوعية: Radiology, Nuclear Medicine and imaging, General Medicine
الوصف: Non-small cell lung cancer (NSCLC) is frequently complicated by central nervous system (CNS) metastases affecting patients’ life expectancy and quality. At the present clinical trials including neurosurgery, radiotherapy (RT) and systemic treatments alone or in combination have provided controversial results. CNS involvement is even more frequent in NSCLC patients with EGFR activating mutations or ALK rearrangement suggesting a role of target therapy in the upfront treatment in place of loco-regionals treatments (i.e. RT and/or surgery). So far clinical research has not explored the potential role of accurate brain imaging (i.e. MRI instead of the routine total-body contrast CT and/or PET/CT staging) to identify patients that could benefit of local therapies. Moreover, for patients who require concomitant RT there are no clear guidelines on the timing of intervention with respect to innovative precision medicine approaches with Tyrosine Kinase Inhibitors, ALK-inhibitors and/or immuno-oncological therapies. On this basis the present review describes the therapeutic strategies integrating medical and radiation oncology in patients with metastatic NSCLC (mNSCLC) adenocarcinoma with CNS involvement and EGFR activating mutations or ALK rearrangement.
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8دورية أكاديمية
المؤلفون: Wachter, Jenny, Cheff, Britney, Hillman, Chad, Carracoi, Valentina, Dorward, David W., Martens, Craig, Barbian, Kent, Nardone, Glenn, Renee Olano, L., Kinnersley, Margie, Secor, Patrick R., Rosa, Patricia A.
المصدر: Nature Communications ; volume 14, issue 1 ; ISSN 2041-1723
مصطلحات موضوعية: General Physics and Astronomy, General Biochemistry, Genetics and Molecular Biology, General Chemistry, Multidisciplinary
الوصف: The alternative sigma factor RpoS plays a central role in the critical host-adaptive response of the Lyme disease spirochete, Borrelia burgdorferi . We previously identified bbd18 as a negative regulator of RpoS but could not inactivate bbd18 in wild-type spirochetes. In the current study we employed an inducible bbd18 gene to demonstrate the essential nature of BBD18 for viability of wild-type spirochetes in vitro and at a unique point in vivo. Transcriptomic analyses of BBD18-depleted cells demonstrated global induction of RpoS-dependent genes prior to lysis, with the absolute requirement for BBD18, both in vitro and in vivo, circumvented by deletion of rpoS . The increased expression of plasmid prophage genes and the presence of phage particles in the supernatants of lysing cultures indicate that RpoS regulates phage lysis-lysogeny decisions. Through this work we identify a mechanistic link between endogenous prophages and the RpoS-dependent adaptive response of the Lyme disease spirochete.
الإتاحة: https://doi.org/10.1038/s41467-023-35897-3Test
https://www.nature.com/articles/s41467-023-35897-3.pdfTest
https://www.nature.com/articles/s41467-023-35897-3Test -
9دورية أكاديمية
المؤلفون: Kanoni, Stavroula, Graham, Sarah E, Wang, Yuxuan, Surakka, Ida, Ramdas, Shweta, Zhu, Xiang, Clarke, Shoa L, Bhatti, Konain Fatima, Vedantam, Sailaja, Winkler, Thomas W, Locke, Adam E, Marouli, Eirini, Zajac, Greg JM, Wu, Kuan-Han H, Ntalla, Ioanna, Hui, Qin, Klarin, Derek, Hilliard, Austin T, Wang, Zeyuan, Xue, Chao, Thorleifsson, Gudmar, Helgadottir, Anna, Gudbjartsson, Daniel F, Holm, Hilma, Olafsson, Isleifur, Hwang, Mi Yeong, Han, Sohee, Akiyama, Masato, Sakaue, Saori, Terao, Chikashi, Kanai, Masahiro, Zhou, Wei, Brumpton, Ben M, Rasheed, Humaira, Havulinna, Aki S, Veturi, Yogasudha, Pacheco, Jennifer Allen, Rosenthal, Elisabeth A, Lingren, Todd, Feng, QiPing, Kullo, Iftikhar J, Narita, Akira, Takayama, Jun, Martin, Hilary C, Hunt, Karen A, Trivedi, Bhavi, Haessler, Jeffrey, Giulianini, Franco, Bradford, Yuki, Miller, Jason E, Campbell, Archie, Lin, Kuang, Millwood, Iona Y, Rasheed, Asif, Hindy, George, Faul, Jessica D, Zhao, Wei, Weir, David R, Turman, Constance, Huang, Hongyan, Graff, Mariaelisa, Choudhury, Ananyo, Sengupta, Dhriti, Mahajan, Anubha, Brown, Michael R, Zhang, Weihua, Yu, Ketian, Schmidt, Ellen M, Pandit, Anita, Gustafsson, Stefan, Yin, Xianyong, Luan, Jian'an, Zhao, Jing-Hua, Matsuda, Fumihiko, Jang, Hye-Mi, Yoon, Kyungheon, Medina-Gomez, Carolina, Pitsillides, Achilleas, Hottenga, Jouke Jan, Wood, Andrew R, Ji, Yingji, Gao, Zishan, Haworth, Simon, Yousri, Noha A, Mitchell, Ruth E, Chai, Jin Fang, Aadahl, Mette, Bjerregaard, Anne A, Yao, Jie, Manichaikul, Ani, Hwu, Chii-Min, Hung, Yi-Jen, Warren, Helen R, Ramirez, Julia, Bork-Jensen, Jette, Kårhus, Line L, Goel, Anuj, Sabater-Lleal, Maria, Noordam, Raymond, Mauro, Pala, Matteo, Floris, McDaid, Aaron F, Marques-Vidal, Pedro, Wielscher, Matthias, Trompet, Stella, Sattar, Naveed, Møllehave, Line T, Munz, Matthias, Zeng, Lingyao, Huang, Jianfeng, Yang, Bin, Poveda, Alaitz, Kurbasic, Azra, Lamina, Claudia, Forer, Lukas, Scholz, Markus, Galesloot, Tessel E, Bradfield, Jonathan P, Ruotsalainen, Sanni E, Daw, EWarwick, Zmuda, Joseph M, Mitchell, Jonathan S, Fuchsberger, Christian, Christensen, Henry, Brody, Jennifer A, Vazquez-Moreno, Miguel, Feitosa, Mary F, Wojczynski, Mary K, Wang, Zhe, Preuss, Michael H, Mangino, Massimo, Christofidou, Paraskevi, Verweij, Niek, Benjamins, Jan W, Engmann, Jorgen, Tsao, Noah L, Verma, Anurag, Slieker, Roderick C, Lo, Ken Sin, Zilhao, Nuno R, Le, Phuong, Kleber, Marcus E, Delgado, Graciela E, Huo, Shaofeng, Ikeda, Daisuke D, Iha, Hiroyuki, Yang, Jian, Liu, Jun, Demirkan, Ayşe, Leonard, Hampton L, Marten, Jonathan, Frank, Mirjam, Schmidt, Börge, Smyth, Laura J, Cañadas-Garre, Marisa, Wang, Chaolong, Nakatochi, Masahiro, Wong, Andrew, Hutri-Kähönen, Nina, Sim, Xueling, Xia, Rui, Huerta-Chagoya, Alicia, Fernandez-Lopez, Juan Carlos, Lyssenko, Valeriya, Nongmaithem, Suraj S, Bayyana, Swati, Stringham, Heather M, Irvin, Marguerite R, Oldmeadow, Christopher, Kim, Han-Na, Ryu, Seungho, Timmers, Paul RHJ, Arbeeva, Liubov, Dorajoo, Rajkumar, Lange, Leslie A, Prasad, Gauri, Lorés-Motta, Laura, Pauper, Marc, Long, Jirong, Li, Xiaohui, Theusch, Elizabeth, Takeuchi, Fumihiko, Spracklen, Cassandra N, Loukola, Anu, Bollepalli, Sailalitha, Warner, Sophie C, Wang, Ya Xing, Wei, Wen B, Nutile, Teresa, Ruggiero, Daniela, Sung, Yun Ju, Chen, Shufeng, Liu, Fangchao, Yang, Jingyun, Kentistou, Katherine A, Banas, Bernhard, Nardone, Giuseppe Giovanni, Meidtner, Karina, Bielak, Lawrence F, Smith, Jennifer A, Hebbar, Prashantha, Farmaki, Aliki-Eleni, Hofer, Edith, Lin, Maoxuan, Concas, Maria Pina, Vaccargiu, Simona, van der Most, Peter J, Pitkänen, Niina, Cade, Brian E, van der Laan, Sander W, Chitrala, Kumaraswamy Naidu, Weiss, Stefan, Bentley, Amy R, Doumatey, Ayo P, Adeyemo, Adebowale A, Lee, Jong Young, Petersen, Eva RB, Nielsen, Aneta A, Choi, Hyeok Sun, Nethander, Maria, Freitag-Wolf, Sandra, Southam, Lorraine, Rayner, Nigel W, Wang, Carol A, Lin, Shih-Yi, Wang, Jun-Sing, Couture, Christian, Lyytikäinen, Leo-Pekka, Nikus, Kjell, Cuellar-Partida, Gabriel, Vestergaard, Henrik, Hidalgo, Bertha, Giannakopoulou, Olga, Cai, Qiuyin, Obura, Morgan O, van Setten, Jessica, Li, Xiaoyin, Liang, Jingjing, Tang, Hua, Terzikhan, Natalie, Shin, Jae Hun, Jackson, Rebecca D, Reiner, Alexander P, Martin, Lisa Warsinger, Chen, Zhengming, Li, Liming, Kawaguchi, Takahisa, Thiery, Joachim, Bis, Joshua C, Launer, Lenore J, Li, Huaixing, Nalls, Mike A, Raitakari, Olli T, Ichihara, Sahoko, Wild, Sarah H, Nelson, Christopher P, Campbell, Harry, Jäger, Susanne, Nabika, Toru, Al-Mulla, Fahd, Niinikoski, Harri, Braund, Peter S, Kolcic, Ivana, Kovacs, Peter, Giardoglou, Tota, Katsuya, Tomohiro, de Kleijn, Dominique, de Borst, Gert J, Kim, Eung Kweon, Adams, Hieab HH, Ikram, M Arfan, Zhu, Xiaofeng, Asselbergs, Folkert W, Kraaijeveld, Adriaan O, Beulens, Joline WJ, Shu, Xiao-Ou, Rallidis, Loukianos S, Pedersen, Oluf, Hansen, Torben, Mitchell, Paul, Hewitt, Alex W, Kähönen, Mika, Pérusse, Louis, Bouchard, Claude, Tönjes, Anke, Chen, Yii-Der Ida, Pennell, Craig E, Mori, Trevor A, Lieb, Wolfgang, Franke, Andre, Ohlsson, Claes, Mellström, Dan, Cho, Yoon Shin, Lee, Hyejin, Yuan, Jian-Min, Koh, Woon-Puay, Rhee, Sang Youl, Woo, Jeong-Taek, Heid, Iris M, Stark, Klaus J, Zimmermann, Martina E, Völzke, Henry, Homuth, Georg, Evans, Michele K, Zonderman, Alan B, Polasek, Ozren, Pasterkamp, Gerard, Hoefer, Imo E, Redline, Susan, Pahkala, Katja, Oldehinkel, Albertine J, Snieder, Harold, Biino, Ginevra, Schmidt, Reinhold, Schmidt, Helena, Bandinelli, Stefania, Dedoussis, George, Thanaraj, Thangavel Alphonse, Kardia, Sharon LR, Peyser, Patricia A, Kato, Norihiro, Schulze, Matthias B, Girotto, Giorgia, Böger, Carsten A, Jung, Bettina, Joshi, Peter K, Bennett, David A, De Jager, Philip L, Lu, Xiangfeng, Mamakou, Vasiliki, Brown, Morris, Caulfield, Mark J, Munroe, Patricia B, Guo, Xiuqing, Ciullo, Marina, Jonas, Jost B, Samani, Nilesh J, Kaprio, Jaakko, Pajukanta, Päivi, Tusié-Luna, Teresa, Aguilar-Salinas, Carlos A, Adair, Linda S, Bechayda, Sonny Augustin, de Silva, H Janaka, Wickremasinghe, Ananda R, Krauss, Ronald M, Wu, Jer-Yuarn, Zheng, Wei, Hollander, Anneke Iden, Bharadwaj, Dwaipayan, Correa, Adolfo, Wilson, James G, Lind, Lars, Heng, Chew-Kiat, Nelson, Amanda E, Golightly, Yvonne M, Wilson, James F, Penninx, Brenda, Kim, Hyung-Lae, Attia, John, Scott, Rodney J, Rao, DC, Arnett, Donna K, Hunt, Steven C, Walker, Mark, Koistinen, Heikki A, Chandak, Giriraj R, Mercader, Josep M, Costanzo, Maria C, Jang, Dongkeun, Burtt, Noël P, Villalpando, Clicerio Gonzalez, Orozco, Lorena, Fornage, Myriam, Tai, EShyong, van Dam, Rob M, Lehtimäki, Terho, Chaturvedi, Nish, Yokota, Mitsuhiro, Liu, Jianjun, Reilly, Dermot F, McKnight, Amy Jayne, Kee, Frank, Jöckel, Karl-Heinz, McCarthy, Mark I, Palmer, Colin NA, Vitart, Veronique, Hayward, Caroline, Simonsick, Eleanor, van Duijn, Cornelia M, Jin, Zi-Bing, Qu, Jia, Hishigaki, Haretsugu, Lin, Xu, März, Winfried, Gudnason, Vilmundur, Tardif, Jean-Claude, Lettre, Guillaume, Hart, Leen M 't, Elders, Petra JM, Damrauer, Scott M, Kumari, Meena, Kivimaki, Mika, van der Harst, Pim, Spector, Tim D, Loos, Ruth JF, Province, Michael A, Parra, Esteban J, Cruz, Miguel, Psaty, Bruce M, Brandslund, Ivan, Pramstaller, Peter P, Rotimi, Charles N, Christensen, Kaare, Ripatti, Samuli, Widén, Elisabeth, Hakonarson, Hakon, Grant, Struan FA, Kiemeney, Lambertus ALM, de Graaf, Jacqueline, Loeffler, Markus, Kronenberg, Florian, Gu, Dongfeng, Erdmann, Jeanette, Schunkert, Heribert, Franks, Paul W, Linneberg, Allan, Jukema, J Wouter, Khera, Amit V, Männikkö, Minna, Jarvelin, Marjo-Riitta, Kutalik, Zoltan, Francesco, Cucca, Mook-Kanamori, Dennis O, van Dijk, Ko Willems, Watkins, Hugh, Strachan, David P, Grarup, Niels, Sever, Peter, Poulter, Neil, Chuang, Lee-Ming, Rotter, Jerome I, Dantoft, Thomas M, Karpe, Fredrik, Neville, Matt J, Timpson, Nicholas J, Cheng, Ching-Yu, Wong, Tien-Yin, Khor, Chiea Chuen, Li, Hengtong, Sabanayagam, Charumathi, Peters, Annette, Gieger, Christian, Hattersley, Andrew T, Pedersen, Nancy L, Magnusson, Patrik KE, Boomsma, Dorret I, Willemsen, Allegonda HM, Cupples, LAdrienne, van Meurs, Joyce BJ, Ghanbari, Mohsen, Gordon-Larsen, Penny, Huang, Wei, Kim, Young Jin, Tabara, Yasuharu, Wareham, Nicholas J, Langenberg, Claudia, Zeggini, Eleftheria, Kuusisto, Johanna, Laakso, Markku, Ingelsson, Erik, Abecasis, Goncalo, Chambers, John C, Kooner, Jaspal S, de Vries, Paul S, Morrison, Alanna C, Hazelhurst, Scott, Ramsay, Michèle, North, Kari E, Daviglus, Martha, Kraft, Peter, Martin, Nicholas G, Whitfield, John B, Abbas, Shahid, Saleheen, Danish, Walters, Robin G, Holmes, Michael V, Black, Corri, Smith, Blair H, Baras, Aris, Justice, Anne E, Buring, Julie E, Ridker, Paul M, Chasman, Daniel I, Kooperberg, Charles, Tamiya, Gen, Yamamoto, Masayuki, van Heel, David A, Trembath, Richard C, Wei, Wei-Qi, Jarvik, Gail P, Namjou, Bahram, Hayes, M Geoffrey, Ritchie, Marylyn D, Jousilahti, Pekka, Salomaa, Veikko, Hveem, Kristian, Åsvold, Bjørn Olav, Kubo, Michiaki, Kamatani, Yoichiro, Okada, Yukinori, Murakami, Yoshinori, Kim, Bong-Jo, Thorsteinsdottir, Unnur, Stefansson, Kari, Zhang, Jifeng, Chen, YEugene, Ho, Yuk-Lam, Lynch, Julie A, Rader, Daniel J, Tsao, Philip S, Chang, Kyong-Mi, Cho, Kelly, O'Donnell, Christopher J, Gaziano, John M, Wilson, Peter WF, Frayling, Timothy M, Hirschhorn, Joel N, Kathiresan, Sekar, Mohlke, Karen L, Sun, Yan V, Morris, Andrew P, Boehnke, Michael, Brown, Christopher D, Natarajan, Pradeep, Deloukas, Panos, Willer, Cristen J, Assimes, Themistocles L, Peloso, Gina M
الوصف: BACKGROUND: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. RESULTS: To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3-5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism. CONCLUSIONS: Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.
وصف الملف: application/octet-stream; application/zip
الإتاحة: https://doi.org/10.17863/CAM.91776Test
https://www.repository.cam.ac.uk/handle/1810/344352Test -
10دورية أكاديمية
المؤلفون: Ogaz, Dana, Logan, Louise, Curtis, Tyrone J, McDonagh, Lorraine, Guerra, Luis, Bradshaw, Daniel, Patel, Poorvi, Macri, Chiara, Murphy, Gary, Noel Gill, O, Johnson, Anne M, Nardone, Anthony, Burns, Fiona
المصدر: BMC Public Health , 22 (1) , Article 1105. (2022)
مصطلحات موضوعية: Bisexual, Gay, HIV, HIV pre-exposure prophylaxis, MSM, Men who have sex with men, PrEP, Adolescent, Adult, Cross-Sectional Studies, HIV Infections, Homosexuality, Male, Humans, London, Pre-Exposure Prophylaxis, Sexual Behavior, Sexual and Gender Minorities, Young Adult
الوصف: BACKGROUND: Access to prevention options, including HIV pre-exposure prophylaxis (PrEP), remains a public health priority for gay, bisexual, and other men who have sex with men (MSM), especially in London. We describe PrEP use in a London community sample of MSM before the introduction of a national PrEP programme in October 2020. METHODS: From June-August 2019, MSM aged ≥ 18 recruited from London commercial venues were asked to self-complete a sexual health questionnaire and provide an oral fluid sample for anonymous HIV antibody testing. Descriptive analyses of demographic characteristics, service engagement and outcomes, as well as sexual risk and prevention behaviours were examined in the survey population and in those reporting current PrEP use. We performed sequential, multivariate analyses examining current PrEP use in MSM of self-perceived HIV-negative/unknown status with identified PrEP-need defined as the report of condomless anal sex (CAS) in the last three months, or the report of CAS (in the last year) with an HIV-positive/unknown status partner not known to be on HIV treatment, in reflection of UK PrEP guidelines. RESULTS: One thousand five hundred and thirty-fifth questionnaires were completed across 34 venues, where 1408 were analysed. One in five MSM of self-perceived HIV-negative/unknown status reported current PrEP use (19.7%, 242/1230). In men with PrEP-need, 68.2% (431/632) did not report current use. Current PrEP use was associated with age (aOR: 3.52, 95% CI: 1.76-7.02 in men aged 40-44 vs men aged 18-25) and education (aOR: 1.72, 95% CI: 1.01-2.92 in men with ≥ 2 years/still full-time vs no/ < 2 years of education since age 16). CONCLUSION: Among MSM in London, PrEP use is high but there is indication of unmet PrEP-need in men of younger age and lower levels of post-16 education. National programme monitoring and evaluation will require continued community monitoring to guide interventions ensuring equitable PrEP access and uptake in those who could most benefit from PrEP.
وصف الملف: text
العلاقة: https://discovery.ucl.ac.uk/id/eprint/10150251/1/s12889-022-13425-0.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10150251Test/
