دورية أكاديمية
Systematic reduction of gray matter volume in anorexia nervosa, but relative enlargement with clinical symptoms in the prefrontal and posterior insular cortices: a multicenter neuroimaging study
| العنوان: | Systematic reduction of gray matter volume in anorexia nervosa, but relative enlargement with clinical symptoms in the prefrontal and posterior insular cortices: a multicenter neuroimaging study |
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| المؤلفون: | Tose, Keima, Takamura, Tsunehiko, Isobe, Masanori, Hirano, Yoshiyuki, Sato, Yasuhiro, Kodama, Naoki, Yoshihara, Kazufumi, Maikusa, Norihide, Moriguchi, Yoshiya, Noda, Tomomi, Mishima, Ryo, Kawabata, Michiko, Noma, Shun’ichi, Takakura, Shu, Gondo, Motoharu, Kakeda, Shingo, Takahashi, Masatoshi, Ide, Satoru, Adachi, Hiroaki, Hamatani, Sayo, Kamashita, Rio, Sudo, Yusuke, Matsumoto, Koji, Nakazato, Michiko, Numata, Noriko, Hamamoto, Yumi, Shoji, Tomotaka, Muratsubaki, Tomohiko, Sugiura, Motoaki, Murai, Toshiya, Fukudo, Shin, Sekiguchi, Atsushi |
| المساهمون: | Japan Agency for Medical Research and Development |
| المصدر: | Molecular Psychiatry ; ISSN 1359-4184 1476-5578 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Cellular and Molecular Neuroscience, Psychiatry and Mental health, Molecular Biology |
| الوصف: | Although brain morphological abnormalities have been reported in anorexia nervosa (AN), the reliability and reproducibility of previous studies were limited due to insufficient sample sizes, which prevented exploratory analysis of the whole brain as opposed to regions of interest (ROIs). Objective was to identify brain morphological abnormalities in AN and the association with severity of AN by brain structural magnetic resonance imaging (MRI) in a multicenter study, and to conduct exploratory analysis of the whole brain. Here, we conducted a cross-sectional multicenter study using T1-weighted imaging (T1WI) data collected between May 2014 and February 2019 in Japan. We analyzed MRI data from 103 female AN patients (58 anorexia nervosa restricting type [ANR] and 45 anorexia nervosa binge-purging type [ANBP]) and 102 age-matched female healthy controls (HC). MRI data from five centers were preprocessed using the latest harmonization method to correct for intercenter differences. Gray matter volume (GMV) was calculated from T1WI data of all participants. Of the 205 participants, we obtained severity of eating disorder symptom scores from 179 participants, including 87 in the AN group (51 ANR, 36 ANBP) and 92 HC using the Eating Disorder Examination Questionnaire (EDE-Q) 6.0. GMV reduction were observed in the AN brain, including the bilateral cerebellum, middle and posterior cingulate gyrus, supplementary motor cortex, precentral gyrus medial segment, and thalamus. In addition, the orbitofrontal cortex (OFC), ventromedial prefrontal cortex (vmPFC), rostral anterior cingulate cortex (ACC), and posterior insula volumes showed positive correlations with severity of symptoms. This multicenter study was conducted with a large sample size to identify brain morphological abnormalities in AN. The findings provide a better understanding of the pathogenesis of AN and have potential for the development of brain imaging biomarkers of AN. Trial Registration: UMIN000017456. ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41380-023-02378-4 |
| الإتاحة: | https://doi.org/10.1038/s41380-023-02378-4Test https://www.nature.com/articles/s41380-023-02378-4.pdfTest https://www.nature.com/articles/s41380-023-02378-4Test |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.3DA448D0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41380-023-02378-4 |
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