Fibroblastic reticular cell lineage convergence in Peyer’s patches governs intestinal immunity
| العنوان: | Fibroblastic reticular cell lineage convergence in Peyer’s patches governs intestinal immunity |
|---|---|
| المؤلفون: | Cristina Gil-Cruz, Mechthild Lütge, George Kollias, Urs Mörbe, Hung-Wei Cheng, Alejandro Prados, Lucas Onder, Vasiliki Koliaraki, Burkhard Ludewig, Christian Perez-Shibayama |
| المصدر: | Nature immunology |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Stromal cell, Peyer’s patch fibroblastic reticular cells, follicular dendritic cells, lymphoid tissue organizer cells, Immunology, Cell, Cell Communication, Biology, Cell fate determination, Article, Transcriptome, Peyer's Patches, 03 medical and health sciences, 0302 clinical medicine, Immune system, Reticular cell, FRC lineages, Intestine, Small, medicine, Animals, Immunology and Allergy, Cell Lineage, Intestinal Mucosa, Progenitor cell, Immunity, Mucosal, Cells, Cultured, Mice, Knockout, Murine hepatitis virus, PP-FRC, Gene Expression Profiling, Gene Expression Regulation, Developmental, Fibroblasts, Gastrointestinal Microbiome, Cell biology, marginal zone reticular cells, Mice, Inbred C57BL, Disease Models, Animal, Phenotype, 030104 developmental biology, Lymphatic system, medicine.anatomical_structure, Host-Pathogen Interactions, T cell zone reticular cells, Single-Cell Analysis, Coronavirus Infections, 030215 immunology |
| الوصف: | Fibroblastic reticular cells (FRCs) determine the organization of lymphoid organs and control immune cell interactions. While the cellular and molecular mechanisms underlying of FRC differentiation in lymph nodes and the splenic white pulp have been elaborated to some extent, in Peyer’s patches (PPs) they remain elusive. Using a combination of single-cell transcriptomics and cell fate-mapping in advanced mouse models, we found that PP formation in the mouse embryo is initiated by an expansion of perivascular FRC precursors, followed by FRC differentiation from subepithelial progenitors. Single-cell transcriptomics and cell fate-mapping confirmed the convergence of perivascular and subepithelial FRC lineages. Furthermore, lineage-specific loss and gain-of-function approaches revealed that the two FRC lineages synergistically direct PP organization, maintain intestinal microbiome homeostasis and control anti-coronavirus immune responses in the gut. Collectively, this study reveals a distinct mosaic patterning program that generates key stromal cell infrastructures for the control of intestinal immunity. |
| تدمد: | 1529-2916 1529-2908 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f766e87372eb2595c23465687af582c5Test https://doi.org/10.1038/s41590-021-00894-5Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f766e87372eb2595c23465687af582c5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15292916 15292908 |
|---|