Coexpression of epidermal growth factor receptor with related factors is associated with a poor prognosis in non-small-cell lung cancer
| العنوان: | Coexpression of epidermal growth factor receptor with related factors is associated with a poor prognosis in non-small-cell lung cancer |
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| المؤلفون: | Daniel E.B. Swinson, Gerard Cox, Kenneth J. O'Byrne |
| المصدر: | British Journal of Cancer |
| بيانات النشر: | Springer Science and Business Media LLC, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Adult, Male, Cancer Research, Lung Neoplasms, EGFR, NSCLC, medicine.disease_cause, Growth factor receptor, Antigens, Neoplasm, Epidermal growth factor, Carcinoma, Non-Small-Cell Lung, Biomarkers, Tumor, Carcinoma, medicine, Humans, Epidermal growth factor receptor, Carbonic Anhydrase IX, Lung cancer, Aged, Carbonic Anhydrases, Retrospective Studies, Tumor marker, biology, Gene Expression Profiling, Molecular and Cellular Pathology, Middle Aged, Models, Theoretical, Prognosis, medicine.disease, Immunohistochemistry, ErbB Receptors, Gene Expression Regulation, Neoplastic, Matrix Metalloproteinase 9, Oncology, CA IX, Cancer research, biology.protein, Female, MMP-9, Carcinogenesis |
| الوصف: | The epidermal growth factor receptor (EGFR) is commonly expressed in non-small-cell lung cancer (NSCLC) and promotes a host of mechanisms involved in tumorigenesis. However, EGFR expression does not reliably predict prognosis or response to EGFR-targeted therapies. The data from two previous studies of a series of 181 consecutive surgically resected stage I-IIIA NSCLC patients who had survived in excess of 60 days were explored. Of these patients, tissue was available for evaluation of EGFR in 179 patients, carbonic anhydrase (CA) IX in 177 patients and matrix metalloproteinase-9 (MMP-9) in 169 patients. We have previously reported an association between EGFR expression and MMP-9 expression. We have also reported that MMP-9 (P=0.001) and perinuclear (p)CA IX (P=0.03) but not EGFR expression were associated with a poor prognosis. Perinuclear CA IX expression was also associated with EGFR expression (P |
| تدمد: | 1532-1827 0007-0920 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::269e764da20e6e180c851ec10097b01dTest https://doi.org/10.1038/sj.bjc.6602149Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....269e764da20e6e180c851ec10097b01d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15321827 00070920 |
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