Pre-to-post diagnosis weight trajectories in colorectal cancer patients with non-metastatic disease
| العنوان: | Pre-to-post diagnosis weight trajectories in colorectal cancer patients with non-metastatic disease |
|---|---|
| المؤلفون: | Paul C. van de Meeberg, Johannes H. W. de Wilt, Fränzel J.B. van Duijnhoven, Renate M. Winkels, Ellen Kampman, Merel Snellen, Moniek van Zutphen, Anne J.M.R. Geijsen, Ewout A. Kouwenhoven, Anouk Geelen, Henk K. van Halteren, Dieuwertje E. Kok, Ernst Jan Spillenaar Bilgen, Evertine Wesselink, Hendriek C. Boshuizen |
| المصدر: | Supportive Care in Cancer, 27, 4, pp. 1541-1549 Supportive Care in Cancer, 27, 1541-1549 Supportive Care in Cancer Supportive Care in Cancer 27 (2019) 4 Supportive Care in Cancer, 27(4), 1541-1549 |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Nutrition and Disease, Colorectal cancer, medicine.medical_treatment, Disease, Gastroenterology, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, 0302 clinical medicine, Weight loss, Voeding en Ziekte, Internal medicine, Weight Loss, medicine, Humans, Chemotherapy, 030212 general & internal medicine, Prospective cohort study, Weight gain, Aged, Netherlands, VLAG, Human Nutrition & Health, business.industry, Body Weight, Weight change, Humane Voeding & Gezondheid, Middle Aged, medicine.disease, Biometris, Oncology, Chemotherapy, Adjuvant, 030220 oncology & carcinogenesis, Disease Progression, Body-Weight Trajectory, Female, Original Article, Observational study, medicine.symptom, Colorectal Neoplasms, business |
| الوصف: | Purpose: Previous studies have shown that > 50% of colorectal cancer (CRC) patients treated with adjuvant chemotherapy gain weight after diagnosis. This may affect long-term health. Therefore, prevention of weight gain has been incorporated in oncological guidelines for CRC with a focus on patients that undergo adjuvant chemotherapy treatment. It is, however, unknown how changes in weight after diagnosis relate to weight before diagnosis and whether weight changes from pre-to-post diagnosis are restricted to chemotherapy treatment. We therefore examined pre-to-post diagnosis weight trajectories and compared them between those treated with and without adjuvant chemotherapy. Methods: We included 1184 patients diagnosed with stages I–III CRC between 2010 and 2015 from an ongoing observational prospective study. At diagnosis, patients reported current weight and usual weight 2 years before diagnosis. In the 2 years following diagnosis, weight was self-reported repeatedly. We used linear mixed models to analyse weight trajectories. Results: Mean pre-to-post diagnosis weight change was −0.8 (95% CI −1.1, −0.4) kg. Post-diagnosis weight gain was + 3.5 (95% CI 2.7, 4.3) kg in patients who had lost ≥ 5% weight before diagnosis, while on average clinically relevant weight gain after diagnosis was absent in the groups without pre-diagnosis weight loss. Pre-to-post diagnosis weight change was similar in patients treated with (−0.1 kg (95%CI −0.8, 0.6)) and without adjuvant chemotherapy (−0.9 kg (95%CI −1.4, −0.5)). Conclusions: Overall, hardly any pre-to-post diagnosis weight change was observed among CRC patients, because post-diagnosis weight gain was mainly observed in patients who lost weight before diagnosis. This was observed independent of treatment with adjuvant chemotherapy. |
| وصف الملف: | application/pdf; application/octet-stream |
| تدمد: | 1433-7339 0941-4355 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae2628fe1e3b555b0533e9f3629d1b94Test https://doi.org/10.1007/s00520-018-4560-zTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ae2628fe1e3b555b0533e9f3629d1b94 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14337339 09414355 |
|---|