Severe Asthma in School-Age Children: Evaluation and Phenotypic Advances
| العنوان: | Severe Asthma in School-Age Children: Evaluation and Phenotypic Advances |
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| المؤلفون: | Anne M. Fitzpatrick, Andrea M. Coverstone, Leonard B. Bacharier |
| المصدر: | Current Allergy and Asthma Reports. 15 |
| بيانات النشر: | Springer Science and Business Media LLC, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Pulmonary and Respiratory Medicine, Pediatrics, medicine.medical_specialty, Allergy, Adolescent, Severe asthma, Immunology, MEDLINE, Inhaled corticosteroids, macromolecular substances, Adrenal Cortex Hormones, Administration, Inhalation, Humans, Immunology and Allergy, Medicine, Anti-Asthmatic Agents, Child, Asthma, School age child, Inhalation, business.industry, medicine.disease, Response to treatment, respiratory tract diseases, Phenotype, business |
| الوصف: | Although the majority of children with asthma have a favorable clinical response to treatment with low to moderate doses of inhaled corticosteroids (ICS), a small subset of children have "severe" asthma characterized by ongoing symptoms and airway inflammation despite treatment with high doses of ICS and even oral corticosteroids. Although there is symptom heterogeneity in the affected children, children with severe asthma share the risk for adverse outcomes, including recurrent and potentially life-threatening exacerbations, which contribute to substantial economic burden. This article reviews current knowledge of severe asthma in school-age children (age 6-17 years) with a focus on recent literature published after January 2012. Clinical management approaches for children with severe asthma are discussed as well as current phenotyping efforts and emerging phenotypic-directed therapies that may be of benefit for subpopulations of children with severe asthma in the future. |
| تدمد: | 1534-6315 1529-7322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af05cbd3ee70e69acae4052710ed210fTest https://doi.org/10.1007/s11882-015-0521-5Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....af05cbd3ee70e69acae4052710ed210f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15346315 15297322 |
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