دورية أكاديمية
B cells in rheumatoid synovitis.
| العنوان: | B cells in rheumatoid synovitis. |
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| المؤلفون: | Weyand, Cornelia M, Seyler, Thorsten M, Goronzy, Jörg J |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2005 |
| المجموعة: | Duke University Libraries: DukeSpace |
| مصطلحات موضوعية: | Animals, Arthritis, Rheumatoid, B-Lymphocytes, Humans, Synovial Membrane, Synovitis |
| جغرافية الموضوع: | England |
| الوصف: | In rheumatoid arthritis, T cells, B cells, macrophages, and dendritic cells invade the synovial membranes, establishing complex microstructures that promote inflammatory/tissue destructive lesions. B cell involvement has been considered to be limited to autoantibody production. However, recent studies suggest that B cells support rheumatoid disease through other mechanisms. A critical element of rheumatoid synovitis is the process of ectopic lymphoid neogenesis, with highly efficient lymphoid architectures established in a nonlymphoid tissue site. Rheumatoid synovitis recapitulates the pathways of lymph node formation, and B cells play a key role in this process. Furthermore, studies of rheumatoid lesions implanted in immunodeficient mice suggest that T cell activation in synovitis is B cell dependent, indicating the role played by B cells in presenting antigens and providing survival signals. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1478-6362 |
| العلاقة: | Arthritis Res Ther; http://www.ncbi.nlm.nih.gov/pubmed/15960820Test; ar1737; https://hdl.handle.net/10161/10370Test |
| الإتاحة: | https://hdl.handle.net/10161/10370Test http://www.ncbi.nlm.nih.gov/pubmed/15960820Test |
| رقم الانضمام: | edsbas.FD813E25 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14786362 |
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