Association between dietary total antioxidant capacity and hepatocellular ballooning in nonalcoholic steatohepatitis: a cross-sectional study
| العنوان: | Association between dietary total antioxidant capacity and hepatocellular ballooning in nonalcoholic steatohepatitis: a cross-sectional study |
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| المؤلفون: | Juliano Machado de Oliveira, Daiane Gonçalves de Oliveira, Helen Hermana Miranda Hermsdorff, Lincoln Eduardo Villela Vieira de Castro Ferreira, Ana Paula Boroni Moreira, Fabiana de Faria Ghetti |
| المصدر: | European Journal of Nutrition. 58:2263-2270 |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, medicine.medical_specialty, Cirrhosis, Cross-sectional study, Medicine (miscellaneous), 030209 endocrinology & metabolism, medicine.disease_cause, Severity of Illness Index, Gastroenterology, Antioxidants, 03 medical and health sciences, 0302 clinical medicine, Non-alcoholic Fatty Liver Disease, Fibrosis, Surveys and Questionnaires, Internal medicine, medicine, Carcinoma, Humans, 030109 nutrition & dietetics, Nutrition and Dietetics, medicine.diagnostic_test, business.industry, Middle Aged, Anthropometry, medicine.disease, Diet, Oxidative Stress, Cross-Sectional Studies, Liver, Liver biopsy, Hepatocytes, Female, Steatosis, business, Oxidative stress |
| الوصف: | Nonalcoholic steatohepatitis (NASH) is characterized by steatosis, lobular inflammation, ballooning, and in some cases, fibrosis, which can progress to cirrhosis and carcinoma. The progression of NASH is closely related to oxidative stress. Dietary intake of antioxidants has been suggested in protection against oxidative damage and related clinical complications. Thus, we evaluated the potential association of dietary total antioxidant capacity (TAC) with disease severity in NASH patients, as well as with anthropometric and body composition markers and biochemical parameters. Thirty-three outpatients with a mean age of 48.4 ± 1.9 years were evaluated. Dietary TAC was estimated from a quantitative food frequency questionnaire. NASH severity, determined by liver biopsy, lifestyle characteristics, occurrence of comorbidities, anthropometry, body composition, and biochemical parameters were assessed. NASH patients who had a higher dietary TAC had fewer ballooned hepatocytes compared to those with a lower TAC (p = 0.024). The patients with the highest dietary TAC had a reduction of approximately 20% in the risk of having many ballooned hepatocytes (OR 0.791; 95% CI 0.643–0.974; p = 0.027). There was no association of steatosis, lobular inflammation, and fibrosis with dietary TAC. The same occurred for lifestyle characteristics, occurrence of comorbidities, anthropometry, body composition, and biochemical parameters. Dietary TAC is higher in patients with lower hepatic injury (ballooning), suggesting a possible role of food intake naturally high in its antioxidant capacity in reducing free radical production and, consequently, oxidative stress. |
| تدمد: | 1436-6215 1436-6207 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6d88161a52bba6e3b7f29f870adaaa8Test https://doi.org/10.1007/s00394-018-1776-0Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....f6d88161a52bba6e3b7f29f870adaaa8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14366215 14366207 |
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