Comparison of Clinical Characteristics and Spermatogenesis in CHH Patients Caused by PROKR2 and FGFR1 Mutations
| العنوان: | Comparison of Clinical Characteristics and Spermatogenesis in CHH Patients Caused by PROKR2 and FGFR1 Mutations |
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| المؤلفون: | Yaling Zhao, Jiangfeng Mao, Yufan Yang, Shuying Li, Xueyan Wu, Min Nie, Ming Hao |
| المصدر: | Reproductive Sciences. 28:3219-3227 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, endocrine system, medicine.medical_specialty, Adolescent, Receptors, Peptide, medicine.drug_class, Receptors, G-Protein-Coupled, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Receptor, Fibroblast Growth Factor, Type 1, Spermatogenesis, Testosterone, 030219 obstetrics & reproductive medicine, business.industry, Hypogonadism, Fibroblast growth factor receptor 1, Obstetrics and Gynecology, Prokineticin receptor 2, Sperm, stomatognathic diseases, 030104 developmental biology, Endocrinology, Mutation, Congenital Hypogonadotropic Hypogonadism, Gonadotropin, business, Follow-Up Studies, Hormone |
| الوصف: | A retrospective study was conducted to investigate the effect of gonadotropin or pulsatile gonadotropin-releasing hormone (GnRH) therapy on spermatogenesis in congenital hypogonadotropic hypogonadism (CHH) patients with PROKR2 (prokineticin receptor 2) or FGFR1 (fibroblast growth factor receptor 1) mutations. Clinical features, gonadotropin levels, testicular volume (TV), and sperm concentration in response to gonadotropin and pulsatile GnRH therapy were compared between groups with PROKR2 and FGFR1 mutations. Twelve patients with PROKR2 gene mutation and fourteen patients with FGFR1 gene mutation were included. The incidence of cryptorchidism in PROKR2 and FGFR1 groups was 16.7% and 50%, respectively (p = 0.110). The baseline TV in the PROKR2 group was larger than that in FGFR1 group (2.0 vs. 1.63, p = 0.047). The initial LH, FSH, and testosterone levels were similar between the two groups. Based on the analysis of achieving spermatogenesis using Kaplan-Meier and log-rank tests, the PROKR2 group demonstrated shorter period of seminal spermatozoa appearance than the FGFR1 group (χ2 = 8.297, p = 0.004); the median duration of achieving spermatogenesis in the PROKR2 and FGFR1 groups was 9 and 16 months, respectively. The PROKR2 mutation group exhibited shorter required time to achieve different sperm concentration thresholds (5, 10, and 15 million/mL) than the FGFR1 mutation group (p = 0.012, 0.024, and 0.040). In conclusion, the PROKR2 group achieved spermatogenesis easily than the FGFR1 group, possibly due to the lower prevalence of cryptorchidism and larger baseline testicular volume in the PROKR2 group. |
| تدمد: | 1933-7205 1933-7191 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b965055a8fa7bed49ba960af8afe92b5Test https://doi.org/10.1007/s43032-021-00609-zTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....b965055a8fa7bed49ba960af8afe92b5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19337205 19337191 |
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