Outcome of SARS-CoV-2 infection is linked to MAIT cell activation and cytotoxicity
| العنوان: | Outcome of SARS-CoV-2 infection is linked to MAIT cell activation and cytotoxicity |
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| المؤلفون: | Léo Bertrand, Antoine C. Monteiro, Jade Ghosn, Christian Boitard, Héloïse Flament, Yazdan Yazdanpanah, Agnès Lehuen, Muriel Andrieu, Karine Bailly, Xavier Lescure, Frédéric Pène, Jean-François Gautier, Diane Descamps, Benjamin Terrier, Benjamin Saintpierre, Sandrine Luce, Christophe Paget, Youenn Jouan, Camille Rousseau, Margarita Hurtado-Nedelec, Renato C. Monteiro, Mustapha Si-Tahar, Matthieu Rouland, Benoit Visseaux, Samuel Lebourgeois, Lucie Cagninacci, Lucie Beaudoin, Nadine Ajzenberg, Anaïs Vallet-Pichard, Amine Toubal, Zouriatou Gouda, Jean-François Timsit, Thomas Baranek, Pauline Soulard, Franck Letourneur |
| المساهمون: | AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire d'Excellence INFLAMEX [Paris], Université Sorbonne Paris Cité (USPC), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Centre d’Etude des Pathologies Respiratoires (CEPR), UMR 1100 (CEPR), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Hôpital Cochin [AP-HP], Hôpital Lariboisière-Fernand-Widal [APHP], Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Gonzalez, Loïc, Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), LabEx Inflamex, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Université Sorbonne Paris Nord, Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| المصدر: | Nature Immunology Nature Immunology, 2021, 22 (3), pp.322-335. ⟨10.1038/s41590-021-00870-z⟩ Nature Immunology, Nature Publishing Group, 2021, 22 (3), pp.322-335. ⟨10.1038/s41590-021-00870-z⟩ |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Interleukin-1beta, Bronchoalveolar Lavage, Severity of Illness Index, Monocytes, Cohort Studies, 0302 clinical medicine, Chlorocebus aethiops, Macrophage, Cytotoxic T cell, Immunology and Allergy, RNA-Seq, Aged, 80 and over, Interleukin-15, Interleukin-18, Middle Aged, Interleukin-10, 3. Good health, [SDV] Life Sciences [q-bio], medicine.anatomical_structure, Cytokine, Female, France, Single-Cell Analysis, medicine.symptom, Cell activation, Adult, Immunology, Inflammation, Mucosal-Associated Invariant T Cells, Immunophenotyping, Proinflammatory cytokine, Young Adult, 03 medical and health sciences, Immune system, medicine, Animals, Humans, Vero Cells, Aged, Interleukin-6, SARS-CoV-2, business.industry, Macrophages, Monocyte, Interleukin-8, COVID-19, Interferon-alpha, 030104 developmental biology, Case-Control Studies, business, 030215 immunology |
| الوصف: | International audience; Immune system dysfunction is paramount in coronavirus disease 2019 (COVID-19) severity and fatality rate. Mucosal-associated invariant T (MAIT) cells are innate-like T cells involved in mucosal immunity and protection against viral infections. Here, we studied the immune cell landscape, with emphasis on MAIT cells, in cohorts totaling 208 patients with various stages of disease. MAIT cell frequency is strongly reduced in blood. They display a strong activated and cytotoxic phenotype that is more pronounced in lungs. Blood MAIT cell alterations positively correlate with the activation of other innate cells, proinflammatory cytokines, notably interleukin (IL)-18, and with the severity and mortality of severe acute respiratory syndrome coronavirus 2 infection. We also identified a monocyte/macrophage interferon (IFN)-α-IL-18 cytokine shift and the ability of infected macrophages to induce the cytotoxicity of MAIT cells in an MR1-dependent manner. Together, our results suggest that altered MAIT cell functions due to IFN-α-IL-18 imbalance contribute to disease severity, and their therapeutic manipulation may prevent deleterious inflammation in COVID-19 aggravation. |
| اللغة: | English |
| تدمد: | 1529-2916 1529-2908 |
| DOI: | 10.1038/s41590-021-00870-z |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bed6009b16e98dae34662fc83e75f4d1Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bed6009b16e98dae34662fc83e75f4d1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15292916 15292908 |
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| DOI: | 10.1038/s41590-021-00870-z |