Anti-angiogenic factors and pre-eclampsia in type 1 diabetic women
| العنوان: | Anti-angiogenic factors and pre-eclampsia in type 1 diabetic women |
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| المؤلفون: | Yongxin Yu, Kristian F. Hanssen, Hanne Scholz, Timothy J. Lyons, Joshua J. Wang, Tore Henriksen, M. K. Menard, K. May, Azar Dashti, K. Lu, Christopher E. Aston, John R. Stanley, Alicia J. Jenkins, Alison Nankervis, Samar M. Hammad, Torun Clausen, Bjorg Lorentzen, Jian Xing Ma, J. C. Scardo, Sarah X. Zhang, Satish K. Garg |
| المصدر: | Diabetologia. 52:160-168 |
| بيانات النشر: | Springer Science and Business Media LLC, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Adult, Placental growth factor, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Angiogenesis Inhibitors, Receptors, Cell Surface, Biology, Preeclampsia, Pre-Eclampsia, Antigens, CD, Pregnancy, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, Nerve Growth Factors, Eye Proteins, Prospective cohort study, Serpins, reproductive and urinary physiology, Glycated Hemoglobin, Type 1 diabetes, Vascular Endothelial Growth Factor Receptor-1, Eclampsia, Endoglin, Membrane Proteins, medicine.disease, Pregnancy Complications, Diabetes Mellitus, Type 1, Endocrinology, Growth Hormone, Female, Tyrosine kinase |
| الوصف: | Elevated anti-angiogenic factors such as soluble fms-like tyrosine kinase 1 (sFlt1), a soluble form of vascular endothelial growth factor receptor, and endoglin, a co-receptor for TGFbeta1, confer high risk of pre-eclampsia in healthy pregnant women. In this multicentre prospective study, we determined levels of these and related factors in pregnant women with type 1 diabetes, a condition associated with a fourfold increase in pre-eclampsia.Maternal serum sFlt1, endoglin, placental growth factor (PlGF) and pigment epithelial derived factor were measured in 151 type 1 diabetic and 24 healthy non-diabetic women at each trimester and at term.Approximately 22% of the diabetic women developed pre-eclampsia, primarily after their third trimester visit. In women with pre-eclampsia (diabetic pre-eclampsia, n = 26) vs those without hypertensive complications (diabetic normotensive, n = 95), significant changes in angiogenic factors were observed, predominantly in the early third trimester and prior to clinical manifestation of pre-eclampsia. Serum sFlt1 levels were increased approximately twofold in type 1 diabetic pre-eclampsia vs type 1 diabetic normotensive women at the third trimester visit (p0.05) and the normal rise of PlGF during pregnancy was blunted (p0.05). Among type 1 diabetic women, third trimester sFlt1 and PlGF were inversely related (r(2) = 42%, p0.0001). Endoglin levels were increased significantly in the diabetic group as a whole vs the non-diabetic group (p0.0001).Higher sFlt1 levels, a blunted PlGF rise and an elevated sFlt1/PlGF ratio are predictive of pre-eclampsia in pregnant women with type 1 diabetes. Elevated endoglin levels in women with type 1 diabetes may confer a predisposition to pre-eclampsia and may contribute to the high incidence of pre-eclampsia in this patient group. |
| تدمد: | 1432-0428 0012-186X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d8cd35c81ffded9c8728f952c5559ceTest https://doi.org/10.1007/s00125-008-1182-xTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6d8cd35c81ffded9c8728f952c5559ce |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14320428 0012186X |
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