Chronological Distribution of Rip Immunoreactivity in the Gerbil Hippocampus During Normal Aging
| العنوان: | Chronological Distribution of Rip Immunoreactivity in the Gerbil Hippocampus During Normal Aging |
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| المؤلفون: | Moo Ho Won, Tae-Cheon Kang, Bonghee Lee, Yong-Sun Kim, Ki-Yeon Yoo, Dong Shoo Kim, In Koo Hwang |
| المصدر: | Neurochemical Research. 31:1119-1125 |
| بيانات النشر: | Springer Science and Business Media LLC, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Male, Aging, endocrine system, medicine.medical_specialty, Central nervous system, Hippocampus, Nerve Tissue Proteins, Biology, Hippocampal formation, Gerbil, Biochemistry, Cellular and Molecular Neuroscience, Myelin, Western blot, Internal medicine, medicine, Animals, medicine.diagnostic_test, Dentate gyrus, Antibodies, Monoclonal, General Medicine, Immunohistochemistry, Oligodendrocyte, Oligodendroglia, medicine.anatomical_structure, Endocrinology, nervous system, Gerbillinae, Neuroscience, Biomarkers |
| الوصف: | Age-dependent studies on oligodendrocytes, which are the myelinating cells in the central nervous system, have been relatively less investigated. We examined age-dependent changes in Rip immunoreactivity and its protein level in the gerbil hippocampus during normal aging using immunohistochemistry and Western blot analysis with Rip antibody, an oligodendrocyte marker. Rip immunoreactivity and its protein level in the hippocampal CA1 region significantly increased at postnatal month 3 (PM 3). Thereafter, they decreased in the hippocampal CA1 region with age. At PM 24, Rip immunoreactive processes in the hippocampal CA1 region markedly decreased in the stratum radiatum. In the hippocampal CA2/3 region and dentate gyrus, the pattern of changes in Rip immunoreactivity and its protein level was similar to those in the hippocampal CA1 region; however, no significant changes were found in the CA2/3 region and dentate gyrus at various age stages. These results indicate that Rip immunoreactivity and protein level in the hippocampal CA1 region decreases significantly at PM 24 compared to the CA2/3 region and dentate gyrus. |
| تدمد: | 1573-6903 0364-3190 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::447d6d538e825388dbb04b686b28a9c8Test https://doi.org/10.1007/s11064-006-9129-4Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....447d6d538e825388dbb04b686b28a9c8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15736903 03643190 |
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