Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections
| العنوان: | Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections |
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| المؤلفون: | Sara Klucking, Ashley P. Barry, Mark B. Feinberg, Franck J. Barrat, Robert L. Coffman, Thomas H. Vanderford, Judith N. Mandl, Rahul Chavan, Natalia Kozyr, Silvija I. Staprans |
| المصدر: | Nature Medicine. 14:1077-1087 |
| بيانات النشر: | Springer Science and Business Media LLC, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | CD4-Positive T-Lymphocytes, Male, Receptors, CCR7, viruses, animal diseases, T cell, Molecular Sequence Data, Simian Acquired Immunodeficiency Syndrome, medicine.disease_cause, General Biochemistry, Genetics and Molecular Biology, Virus, Cercocebus atys, Immune system, medicine, Animals, Humans, Amino Acid Sequence, Acquired Immunodeficiency Syndrome, Innate immune system, biology, NF-kappa B, Interferon-alpha, virus diseases, Dendritic Cells, General Medicine, Simian immunodeficiency virus, biology.organism_classification, Type I interferon production, Macaca mulatta, Virology, Killer Cells, Natural, medicine.anatomical_structure, Toll-Like Receptor 7, Viral replication, Toll-Like Receptor 9, Immunology, Sooty mangabey, Female, Disease Susceptibility, Signal Transduction |
| الوصف: | Pathogenic HIV infections of humans and simian immunodeficiency virus (SIV) infections of rhesus macaques are characterized by generalized immune activation and progressive CD4(+) T cell depletion. In contrast, natural reservoir hosts for SIV, such as sooty mangabeys, do not progress to AIDS and show a lack of aberrant immune activation and preserved CD4(+) T cell populations, despite high levels of SIV replication. Here we show that sooty mangabeys have substantially reduced levels of innate immune system activation in vivo during acute and chronic SIV infection and that sooty mangabey plasmacytoid dendritic cells (pDCs) produce markedly less interferon-alpha in response to SIV and other Toll-like receptor 7 and 9 ligands ex vivo. We propose that chronic stimulation of pDCs by SIV and HIV in non-natural hosts may drive the unrelenting immune system activation and dysfunction underlying AIDS progression. Such a vicious cycle of continuous virus replication and immunopathology is absent in natural sooty mangabey hosts. |
| تدمد: | 1546-170X 1078-8956 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60b68c2e96721e3c8ea6cbb9513753a4Test https://doi.org/10.1038/nm.1871Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....60b68c2e96721e3c8ea6cbb9513753a4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1546170X 10788956 |
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