The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis
| العنوان: | The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis |
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| المؤلفون: | Stephan J. Reshkin, Rosa Angela Cardone, Valeria Casavola |
| المصدر: | Nature Reviews Cancer. 5:786-795 |
| بيانات النشر: | Springer Science and Business Media LLC, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Sodium-Hydrogen Exchangers, General Mathematics, Cell, Biology, Mice, Neoplasms, medicine, Extracellular, Animals, Humans, Neoplasm Invasiveness, Neoplasm Metastasis, Cation Transport Proteins, Sodium-Hydrogen Exchanger 1, Applied Mathematics, Membrane Proteins, Cell migration, Hydrogen-Ion Concentration, Cell biology, Sodium–hydrogen antiporter, medicine.anatomical_structure, Cancer cell, Invadopodia, Signal transduction, Cotransporter, Signal Transduction |
| الوصف: | Recent research has highlighted the fundamental role of the tumour's extracellular metabolic microenvironment in malignant invasion. This microenvironment is acidified primarily by the tumour-cell Na(+)/H(+) exchanger NHE1 and the H(+)/lactate cotransporter, which are activated in cancer cells. NHE1 also regulates formation of invadopodia - cell structures that mediate tumour cell migration and invasion. How do these alterations of the metabolic microenvironment and cell invasiveness contribute to tumour formation and progression? |
| تدمد: | 1474-1768 1474-175X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::245774cb78e4d986a5b151cce4637e55Test https://doi.org/10.1038/nrc1713Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....245774cb78e4d986a5b151cce4637e55 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14741768 1474175X |
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