Soluble BAFF Cytokine Levels and Antibody-Mediated Rejection of the Kidney Allograft
| العنوان: | Soluble BAFF Cytokine Levels and Antibody-Mediated Rejection of the Kidney Allograft |
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| المؤلفون: | Ondrej Viklicky, Jelena Skibova, Eva Honsova, Janka Slatinska, I. Striz, Jitka Brozova, Zuzana Sekerkova, Antonij Slavcev |
| المصدر: | Archivum Immunologiae et Therapiae Experimentalis. 64:47-53 |
| بيانات النشر: | Springer Science and Business Media LLC, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, Graft Rejection, Male, Risk, 0301 basic medicine, Time Factors, medicine.medical_treatment, Immunology, Human leukocyte antigen, 030230 surgery, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, HLA Antigens, Isoantibodies, B-Cell Activating Factor, medicine, Humans, Immunology and Allergy, Renal Insufficiency, B-cell activating factor, Kidney transplantation, Aged, Aged, 80 and over, B-Lymphocytes, Kidney, biology, business.industry, General Medicine, Middle Aged, medicine.disease, Kidney Transplantation, Tissue Donors, Transplantation, 030104 developmental biology, medicine.anatomical_structure, Cytokine, Antibody mediated rejection, biology.protein, Female, Antibody, business |
| الوصف: | The B-cell activating factor (BAFF) cytokine has important functions for the survival and maturation of B lymphocytes, which implies that this cytokine might play a role in the development of antibody-mediated rejection (AMR) after kidney transplantation. In our study, we compared the concentrations of the soluble BAFF cytokine in kidney graft recipients with AMR and patients without rejection with the goal of testing the hypothesis whether BAFF level measurement might be useful as a diagnostic marker of AMR. The study included a cohort of 19 high-risk patients with diagnosed AMR and 17 control patients free of rejection. BAFF was measured in all patients before transplantation, during the rejection episodes, and three months after transplantation in patients free of rejection using the Luminex technique. Before transplantation, the serum concentrations of BAFF in patients with AMR and kidney recipients without rejection did not significantly differ. After transplantation, however, BAFF levels were significantly lower in patients with AMR and also in patients with concurrent humoral and cellular rejection compared with patients without rejection (p |
| تدمد: | 1661-4917 0004-069X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc75c2778b48406182e3cf00c952bfb5Test https://doi.org/10.1007/s00005-016-0428-4Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....bc75c2778b48406182e3cf00c952bfb5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16614917 0004069X |
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