Development of a tomato-based food for special medical purposes as therapy adjuvant for patients with HCV infection
| العنوان: | Development of a tomato-based food for special medical purposes as therapy adjuvant for patients with HCV infection |
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| المؤلفون: | Vincenzo Fogliano, S Stingo, Paola Vitaglione, Nicola Caporaso, Luca Scalfi, Filomena Morisco |
| المساهمون: | Vitaglione, Paola, Fogliano, Vincenzo, Stingo, S, Scalfi, Luca, Caporaso, Nicola, Morisco, Filomena |
| المصدر: | European Journal of Clinical Nutrition. 61:906-915 |
| بيانات النشر: | Springer Science and Business Media LLC, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Adult, Male, Vitamin, medicine.medical_specialty, Hepatitis C virus, medicine.medical_treatment, Biological Availability, Nutritional Status, Medicine (miscellaneous), medicine.disease_cause, Antiviral Agents, Gastroenterology, Antioxidants, law.invention, Transaminase, chemistry.chemical_compound, Lycopene, Solanum lycopersicum, Randomized controlled trial, law, Internal medicine, medicine, Adjuvant therapy, Humans, Adjuvants, Pharmaceutic, Aged, Nutrition and Dietetics, business.industry, Ribavirin, Middle Aged, Carotenoids, Hepatitis C, Clinical trial, chemistry, Immunology, Female, business, Oxidation-Reduction, Adjuvant |
| الوصف: | OBJECTIVE: The present study aimed to develop a food for special medical purposes (FSMP) and to assess its efficacy as adjuvant therapy in patients with chronic hepatitis C virus (HCV). DESIGN: Open randomized clinical trials with a tomato-based FSMP used as adjuvant treatment to the pharmacological therapy with pegilated interferon and ribavirin. SUBJECTS: Eight healthy volunteers and 39 HCV patients. INTERVENTIONS: For the bioavailability study, healthy subjects consumed 100 g/die FSMP for a week and their serum carotenoid profile at baseline, after the week of administration and 7 days later was determined. The same quantity of FSMP for 6 months by 20 of the 39 HCV patients was consumed in the clinical trial. Serum transaminase, haemoglobin (Hb) and hydroperoxide concentrations during the therapy were monitored in all patients. RESULTS: FSMP consumption caused a fourfold increase of lycopene serum concentration in healthy subjects. A significant increase of carotenoids after 1 month of consumption also in patients with HCV was recorded. Transaminase and Hb serum levels, as well as therapeutic response, were not influenced by FSMP. The decrease in serum hydroperoxides was independent from FSMP consumption in long-term responder patients, whereas nonresponder (NR) patients of FSMP group showed higher reductions than NR patients of Control group. CONCLUSIONS: The FSMP was effective in improving carotenoid status in healthy subjects. In HCV patients, it did not influence the therapeutic response, but it prevented carotenoid serum depletion and it was effective in improving the oxidative status during antiviral therapy in NR patients |
| وصف الملف: | STAMPA |
| تدمد: | 1476-5640 0954-3007 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a09aad874dcf0549a7769338c899fefTest https://doi.org/10.1038/sj.ejcn.1602571Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7a09aad874dcf0549a7769338c899fef |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14765640 09543007 |
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