Multiple-input multiple-output causal strategies for gene selection
| العنوان: | Multiple-input multiple-output causal strategies for gene selection |
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| المؤلفون: | Christine Desmedt, Christos Sotiriou, John Quackenbush, Gianluca Bontempi, Benjamin Haibe-Kains |
| المصدر: | BMC bioinformatics, 12 BMC Bioinformatics BMC Bioinformatics, Vol 12, Iss 1, p 458 (2011) |
| بيانات النشر: | Springer Science and Business Media LLC, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Generalization, Breast Neoplasms, Biology, lcsh:Computer applications to medicine. Medical informatics, computer.software_genre, Biochemistry, Correlation, 03 medical and health sciences, Bayes' theorem, 0302 clinical medicine, Structural Biology, Humans, Relevance (information retrieval), Causation, lcsh:QH301-705.5, Molecular Biology, Oligonucleotide Array Sequence Analysis, 030304 developmental biology, 0303 health sciences, Interpretation (logic), Gene Expression Profiling, Applied Mathematics, Bayes Theorem, Sciences biomédicales, Computer Science Applications, Term (time), Cancérologie, Gene expression profiling, lcsh:Biology (General), 030220 oncology & carcinogenesis, lcsh:R858-859.7, Female, Data mining, computer, Algorithms, Software, Research Article |
| الوصف: | Traditional strategies for selecting variables in high dimensional classification problems aim to find sets of maximally relevant variables able to explain the target variations. If these techniques may be effective in generalization accuracy they often do not reveal direct causes. The latter is essentially related to the fact that high correlation (or relevance) does not imply causation. In this study, we show how to efficiently incorporate causal information into gene selection by moving from a single-input single-output to a multiple-input multiple-output setting. Journal Article Research Support, N.I.H. Extramural Research Support, Non-U.S. Gov't SCOPUS: ar.j info:eu-repo/semantics/published |
| وصف الملف: | 2 full-text file(s): application/pdf; application/pdf |
| تدمد: | 1471-2105 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5c3c4ed5c9a2c09455e6122e7ffb367Test https://doi.org/10.1186/1471-2105-12-458Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f5c3c4ed5c9a2c09455e6122e7ffb367 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712105 |
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