Ultrastructure of ECL cells in Mastomys after long-term treatment with H2 receptor antagonist loxtidine
| العنوان: | Ultrastructure of ECL cells in Mastomys after long-term treatment with H2 receptor antagonist loxtidine |
|---|---|
| المؤلفون: | Reidar Alexander Vigen, Irvin M. Modlin, Duan Chen, Mark Kidd, Chun-Mei Zhao |
| المصدر: | Medical Molecular Morphology. 45:80-85 |
| بيانات النشر: | Springer Science and Business Media LLC, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Male, endocrine system, medicine.medical_specialty, Enterochromaffin-like Cells, Carcinoid Tumor, Lipofuscin, Pathology and Forensic Medicine, Rats, Sprague-Dawley, Mice, Microscopy, Electron, Transmission, Histamine H2 receptor, Stomach Neoplasms, Internal medicine, Autophagy, medicine, Animals, Enterochromaffin-like cell, Molecular Biology, Omeprazole, Gastrin, Inclusion Bodies, Mice, Knockout, Hyperplasia, biology, General Medicine, Triazoles, Anti-Ulcer Agents, biology.organism_classification, medicine.disease, Receptor, Cholecystokinin B, Rats, Endocrinology, Histamine H2 Antagonists, Mastomys, Vacuoles, Ultrastructure, Female, Murinae, medicine.drug |
| الوصف: | Gastric ECL-cell hyperplasia and carcinoids (ECLoma) develop after 1 year in rats treated with omeprazole or 2 months in Mastomys treated with loxtidine. The aim of this study was to examine the ultrastructure of ECL cells in Mastomys after loxtidine treatment with an attempt to evaluate whether an impairment of autophagy was involved in the tumorigenesis. Mastomys were given loxtidine for 8 or 27 weeks. Morphological analysis of ECL cells showed that (1) cell size was not increased after 8 or 27 weeks; (2) secretory vesicles, a hallmark feature of welldifferentiated ECL cells, were unchanged after 8 weeks but reduced after 27 weeks; (3) granules were reduced after 8 or 27 weeks; (4) microvesicles were unchanged after the treatment; and (5) vacuoles and lipofuscin bodies were found occasionally after 8 weeks but not at 27 weeks. In addition, the appearance of ECL-cell ultrastructure differed between loxtidine-treated Mastomys and rats treated with omeprazole or subjected to antrectomy, but was similar between Mastomys treated with loxtidine for 27 weeks and mice deficient in CCK(2) receptor. We suggest that the ultrastructure of ECL cells in Mastomys after long-term treatment with loxtidine displayed an impaired formation of vacuoles and lipofuscin bodies, markers of the autophagic pathway. |
| تدمد: | 1860-1499 1860-1480 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbbfd1e62d4010935f0c942cdef701b8Test https://doi.org/10.1007/s00795-011-0544-5Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....dbbfd1e62d4010935f0c942cdef701b8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18601499 18601480 |
|---|