Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs
| العنوان: | Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs |
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| المؤلفون: | Birthe Sauter, Nina Bhardwaj, Matthew L. Albert |
| المصدر: | Nature. 392:86-89 |
| بيانات النشر: | Springer Science and Business Media LLC, 1998. |
| سنة النشر: | 1998 |
| مصطلحات موضوعية: | Antigen presentation, CD1, Apoptosis, Lymphocyte Activation, Major histocompatibility complex, Monocytes, Cell Line, HLA-A2 Antigen, MHC class I, Humans, Cytotoxic T cell, Antigen-presenting cell, Antigens, Viral, Antigen Presentation, Multidisciplinary, biology, Antigen processing, Macrophages, Histocompatibility Antigens Class I, Cross-presentation, Dendritic Cells, Coculture Techniques, Cell biology, Influenza A virus, Immunology, biology.protein, T-Lymphocytes, Cytotoxic |
| الوصف: | CD8+ cytotoxic T lymphocytes (CTLs) mediate resistance to infectious agents and tumours. Classically, CTLs recognize antigens that are localized in the cytoplasm of target cells, processed and presented as peptide complexes with class I molecules of the major histocompatibility complex (MHC). However, there is evidence for an exogenous pathway whereby antigens that are not expected to gain access to the cytoplasm are presented on MHC class I molecules. The most dramatic example is the in vivo phenomenon of cross-priming: antigens from donor cells are acquired by bone-marrow-derived host antigen-presenting cells (APCs) and presented on MHC class I molecules. Two unanswered questions concern the identity of this bone-marrow-derived cell and how such antigens are acquired. Here we show that human dendritic cells, but not macrophages, efficiently present antigen derived from apoptotic cells, stimulating class I-restricted CD8+ CTLs. Our findings suggest a mechanism by which potent APCs acquire antigens from tumours, transplants, infected cells, or even self-tissue, for stimulation or tolerization of CTLs. |
| تدمد: | 1476-4687 0028-0836 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5ec8afb24d9a3f9830a2d3341cf09e5Test https://doi.org/10.1038/32183Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....e5ec8afb24d9a3f9830a2d3341cf09e5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14764687 00280836 |
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