(—)-Epigallocatechin-3-gallate interferes with mast cell adhesiveness, migration and its potential to recruit monocytes
| العنوان: | (—)-Epigallocatechin-3-gallate interferes with mast cell adhesiveness, migration and its potential to recruit monocytes |
|---|---|
| المؤلفون: | Luis M. Botana, Francisca Sánchez-Jiménez, Mercedes Domínguez, Luis Escribano, Miguel Ángel Medina, José Luis Urdiales, Esther Melgarejo, A. Orfao |
| المصدر: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| بيانات النشر: | Springer Science and Business Media LLC, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Integrins, Chemokine, Angiogenesis, Integrin, Neovascularization, Physiologic, Antineoplastic Agents, CCL8, Catechin, Monocytes, Cell Line, Cellular and Molecular Neuroscience, Immune system, Cell Movement, Cell Adhesion, medicine, Humans, Mast Cells, Molecular Biology, Pharmacology, biology, Gene Expression Profiling, Monocyte, Cell Biology, Mast cell, Cell biology, medicine.anatomical_structure, Gene Expression Regulation, Cell culture, biology.protein, Molecular Medicine |
| الوصف: | Mast cells are multipotent effector cells of the immune system. They are able to induce and enhance angiogenesis via multiple pathways. (-)-Epigallocatechin-3-gallate (EGCG), a major component of green tea and a putative chemopreventive agent, was reported to inhibit tumor invasion and angiogenesis, processes that are essential for tumor growth and metastasis. Using the human mast cell line HMC-1 and commercial cDNA macroarrays, we evaluated the effect of EGCG on the expression of angiogenesis-related genes. Our data show that among other effects, EGCG treatment reduces expression of two integrins (α5 and β3) and a chemokine (MCP1), resulting in a lower adhesion of mast cells associated with a decreased potential to produce signals eliciting monocyte recruitment. These effects on gene expression levels are functionally validated by showing inhibitory effects in adhesion, aggregation, migration and recruitment assays. © 2007 Birkhäuser Verlag. This work was supported by PI05–0327, the Spanish Network of Mastocytosis and CIBERER (MSC, Spain), Ramón-Areces Foundation, grants SAF2005–01812 (MEC, Spain), grants CVI-657 and CVI-267 (Andalusian Research Program, PAI, Andalusia, Spain) to, F.S.J. and Fondo de Investigaciones Sanitarias (FIS, MSC, Spain) (06/0529) and Fundación MMA, Spain to, L.E. |
| تدمد: | 1420-9071 1420-682X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4d7996f51bf82c8db4d50582a50bfc4Test https://doi.org/10.1007/s00018-007-7331-4Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c4d7996f51bf82c8db4d50582a50bfc4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14209071 1420682X |
|---|