Gallic acid improves cardiac dysfunction and fibrosis in pressure overload-induced heart failure
| العنوان: | Gallic acid improves cardiac dysfunction and fibrosis in pressure overload-induced heart failure |
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| المؤلفون: | Hae Jin Kee, Hyung-Seok Kim, Bin Liu, Gwi Ran Kim, Zhe Hao Piao, Li Jin, Sin Young Choi, Myung Ho Jeong, Simei Sun, Yuhee Ryu |
| المصدر: | Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018) Scientific Reports |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, lcsh:Medicine, Cardiomegaly, Constriction, Pathologic, Pharmacology, Article, Transforming Growth Factor beta1, Mice, 03 medical and health sciences, chemistry.chemical_compound, Atrial natriuretic peptide, Fibrosis, Gallic Acid, Pressure, medicine, Animals, Gallic acid, lcsh:Science, Carvedilol, Aorta, Heart Failure, Pressure overload, Multidisciplinary, business.industry, lcsh:R, Furosemide, Heart, medicine.disease, Brain natriuretic peptide, 030104 developmental biology, Gene Expression Regulation, chemistry, Heart failure, cardiovascular system, lcsh:Q, business, Biomarkers, medicine.drug |
| الوصف: | Gallic acid is a trihydroxybenzoic acid found in tea leaves and some plants. Here, we report the effect of gallic acid on cardiac dysfunction and fibrosis in a mouse model of pressure overload-induced heart failure and in primary rat cardiac fibroblasts, and compare the effects of gallic acid with those of drugs used in clinics. Gallic acid reduces cardiac hypertrophy, dysfunction, and fibrosis induced by transverse aortic constriction (TAC) stimuli in vivo and transforming growth factor β1 (TGF-β1) in vitro. It decreases left ventricular end-diastolic and end-systolic diameter, and recovers the reduced fractional shortening in TAC. In addition, it suppresses the expression of atrial natriuretic peptide, brain natriuretic peptide, skeletal α-actin, and β-myosin heavy chain. Administration of gallic acid decreases perivascular fibrosis, as determined by Trichrome II Blue staining, and reduces the expression of collagen type I and connective tissue growth factor. However, administration of losartan, carvedilol, and furosemide does not reduce cardiac dysfunction and fibrosis in TAC. Moreover, treatment with gallic acid inhibits fibrosis-related genes and deposition of collagen type I in TGF-β1-treated cardiac fibroblasts. These results suggest that gallic acid is a therapeutic agent for cardiac dysfunction and fibrosis in chronic heart failure. |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2251ee0ab594a8f200feca735efe3cTest https://doi.org/10.1038/s41598-018-27599-4Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6b2251ee0ab594a8f200feca735efe3c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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