Beta-Amyloid Precursor Protein (βAPP) Processing in Alzheimer’s Disease (AD) and Age-Related Macular Degeneration (AMD)
| العنوان: | Beta-Amyloid Precursor Protein (βAPP) Processing in Alzheimer’s Disease (AD) and Age-Related Macular Degeneration (AMD) |
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| المؤلفون: | Brandon M. Jones, Christian Clement, James M. Hill, Walter J. Lukiw, Prerna Dua, Kumar Sambamurti, Yuhai Zhao, Surjyadipta Bhattacharjee |
| المصدر: | Molecular Neurobiology. 52:533-544 |
| بيانات النشر: | Springer Science and Business Media LLC, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Pathology, medicine.medical_specialty, Amyloid, Amyloid beta, BACE1-AS, Neuroscience (miscellaneous), Biology, Article, Epigenesis, Genetic, Macular Degeneration, Cellular and Molecular Neuroscience, Alzheimer Disease, medicine, Animals, Humans, Senile plaques, Amyloid beta-Peptides, P3 peptide, Macular degeneration, medicine.disease, Biochemistry of Alzheimer's disease, Disease Models, Animal, Neurology, biology.protein, Alzheimer's disease, Protein Processing, Post-Translational |
| الوصف: | Amyloid is a generic term for insoluble, often intensely hydrophobic, fibrous protein aggregates that arise from inappropriately folded versions of naturally-occurring polypeptides. The abnormal generation and accumulation of amyloid, often referred to as amyloidogenesis, has been associated with the immune and pro-inflammatory pathology of several progressive age-related diseases of the human central nervous system (CNS) including Alzheimer's disease (AD) and age-related macular degeneration (AMD). This 'research perspective' paper reviews some of the research history, biophysics, molecular-genetics and environmental factors concerning the contribution of amyloid beta (Aβ) peptides, derived from beta-amyloid precursor protein (βAPP), to AD and AMD that suggests an extensive similarity in immune and inflammatory degenerative mechanisms between these two CNS diseases. |
| تدمد: | 1559-1182 0893-7648 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a1559730952bba570ed12e8c54a47fTest https://doi.org/10.1007/s12035-014-8886-3Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....87a1559730952bba570ed12e8c54a47f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15591182 08937648 |
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