التفاصيل البيبلوغرافية
| العنوان: |
Knee osteoarthritis and time-to all-cause mortality in six community-based cohorts: an international meta-analysis of individual participant-level data |
| المؤلفون: |
Leyland, Kirsten M., Gates, Lucy S., Sanchez-Santos, Maria T., Nevitt, Michael C., Felson, David, Jones, Graeme, Jordan, Joanne M., Judge, Andrew, Prieto-Alhambra, Dani, Yoshimura, Noriko, Newton, Julia L., Callahan, Leigh F., Cooper, Cyrus, Batt, Mark E., Lin, Jianhao, Liu, Qiang, Cleveland, Rebecca J., Collins, Gary S., Arden, Nigel K., March, Lyn, Hawker, Gillian, Conaghan, Philip, Kraus, Virginia Byers, Guermazi, Ali, Hunter, David, Katz, Jeffrey N., McAlindon, Tim, Neogi, Tuhina, Simon, Lee, Cross, Marita, King, Lauren |
| المساهمون: |
Versus Arthritis, University of Oxford |
| المصدر: |
Aging Clinical and Experimental Research ; volume 33, issue 3, page 529-545 ; ISSN 1720-8319 |
| بيانات النشر: |
Springer Science and Business Media LLC |
| سنة النشر: |
2021 |
| مصطلحات موضوعية: |
Geriatrics and Gerontology, Aging |
| الوصف: |
Background Osteoarthritis (OA) is a chronic joint disease, with increasing global burden of disability and healthcare utilisation. Recent meta-analyses have shown a range of effects of OA on mortality, reflecting different OA definitions and study methods. We seek to overcome limitations introduced when using aggregate results by gathering individual participant-level data (IPD) from international observational studies and standardising methods to determine the association of knee OA with mortality in the general population. Methods Seven community-based cohorts were identified containing knee OA-related pain, radiographs, and time-to-mortality, six of which were available for analysis. A two-stage IPD meta-analysis framework was applied: (1) Cox proportional hazard models assessed time-to-mortality of participants with radiographic OA (ROA), OA-related pain (POA), and a combination of pain and ROA (PROA) against pain and ROA-free participants; (2) hazard ratios (HR) were then pooled using the Hartung–Knapp modification for random-effects meta-analysis. Findings 10,723 participants in six cohorts from four countries were included in the analyses. Multivariable models (adjusting for age, sex, race, BMI, smoking, alcohol consumption, cardiovascular disease, and diabetes) showed a pooled HR, compared to pain and ROA-free participants, of 1.03 (0.83, 1.28) for ROA, 1.35 (1.12, 1.63) for POA, and 1.37 (1.22, 1.54) for PROA. Discussion Participants with POA or PROA had a 35–37% increased association with reduced time-to-mortality, independent of confounders. ROA showed no association with mortality, suggesting that OA-related knee pain may be driving the association with time-to-mortality. Funding Versus Arthritis Centre for Sport, Exercise and Osteoarthritis and Osteoarthritis Research Society International. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1007/s40520-020-01762-2 |
| DOI: |
10.1007/s40520-020-01762-2.pdf |
| DOI: |
10.1007/s40520-020-01762-2/fulltext.html |
| الإتاحة: |
https://doi.org/10.1007/s40520-020-01762-2Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: |
edsbas.72518AC7 |
| قاعدة البيانات: |
BASE |
