Genotypic Resistance Tests Sequences Reveal the Role of Marginalized Populations in HIV-1 Transmission in Switzerland
| العنوان: | Genotypic Resistance Tests Sequences Reveal the Role of Marginalized Populations in HIV-1 Transmission in Switzerland |
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| المؤلفون: | Shilaih Mohaned, Marzel Alex, Yang Wan Lin, Scherrer Alexandra U., Schupbach Jorg, Boni Jurg, Yerly Sabine, Hirsch Hans H., Aubert Vincent, Cavassini Matthias, Klimkait Thomas, Vernazza Pietro L., Bernasconi Enos, Furrer Hansjakob, Gunthard Huldrych F., Kouyos Roger, Study Swiss HIV Cohort |
| المساهمون: | Swiss HIV Cohort Study, Battegay, M., Braun, D., Bucher, H., Burton-Jeangros, C., Calmy, A., Dollenmaier, G., Egger, M., Elzi, L., Fehr, J., Fellay, J., Fux, C., Gorgievski, M., Haerry, D., Hasse, B., Hoffmann, M., Hösli, I., Kahlert, C., Kaiser, L., Keiser, O., Kovari, H., Ledergerber, B., Martinetti, G., de Tejada, B.M., Marzolini, C., Metzner, K., Müller, N., Nadal, D., Nicca, D., Pantaleo, G., Rauch, A., Regenass, S., Rudin, C., Schöni-Affolter, F., Schmid, P., Speck, R., Stöckle, M., Tarr, P., Trkola, A., Weber, R., University of Zurich, Shilaih, Mohaned |
| المصدر: | Scientific reports, vol. 6, pp. 27580 Scientific Reports, Vol. 6 (2016) P. 27580 SCIENTIFIC REPORTS Shilaih, Mohaned; Marzel, Alex; Yang, Wan Lin; Scherrer, Alexandra U; Schüpbach, Jörg; Böni, Jürg; Yerly, Sabine; Hirsch, Hans H; Aubert, Vincent; Cavassini, Matthias; Klimkait, Thomas; Vernazza, Pietro L; Bernasconi, Enos; Furrer, Hansjakob; Günthard, Huldrych F; Kouyos, Roger (2016). Genotypic Resistance Tests Sequences Reveal the Role of Marginalized Populations in HIV-1 Transmission in Switzerland. Scientific Reports, 6(27580), p. 27580. Nature Publishing Group 10.1038/srep27580 <http://dx.doi.org/10.1038/srep27580Test> Scientific Reports |
| بيانات النشر: | Springer Science and Business Media LLC, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, Male, 10028 Institute of Medical Virology, 0301 basic medicine, Multivariate analysis, Genotype, Anti-HIV Agents, Anti-HIV Agents/therapeutic use, Cohort Studies, Drug Resistance, Viral/genetics, Female, HIV Infections/drug therapy, HIV Infections/epidemiology, HIV Infections/transmission, HIV Infections/virology, HIV-1/classification, HIV-1/genetics, HIV-1/isolation & purification, Heterosexuality, Homosexuality, Male, Humans, Middle Aged, Molecular Typing, Multivariate Analysis, Phylogeny, Substance Abuse, Intravenous/drug therapy, Substance Abuse, Intravenous/epidemiology, Substance Abuse, Intravenous/virology, Switzerland/epidemiology, HIV Infections, 610 Medicine & health, Biology, Logistic regression, Article, law.invention, 10234 Clinic for Infectious Diseases, 03 medical and health sciences, 0302 clinical medicine, law, Drug Resistance, Viral, 030212 general & internal medicine, Substance Abuse, Intravenous, ddc:616, Genetics, 1000 Multidisciplinary, Multidisciplinary, Phylogenetic tree, Outbreak, Confidence interval, 3. Good health, 030104 developmental biology, Transmission (mechanics), HIV-1, Switzerland, Demography, Cohort study |
| الوصف: | Targeting hard-to-reach/marginalized populations is essential for preventing HIV-transmission. A unique opportunity to identify such populations in Switzerland is provided by a database of all genotypic-resistance-tests from Switzerland, including both sequences from the Swiss HIV Cohort Study (SHCS) and non-cohort sequences. A phylogenetic tree was built using 11,127 SHCS and 2,875 Swiss non-SHCS sequences. Demographics were imputed for non-SHCS patients using a phylogenetic proximity approach. Factors associated with non-cohort outbreaks were determined using logistic regression. Non-B subtype (univariable odds-ratio (OR): 1.9; 95% confidence interval (CI): 1.8–2.1), female gender (OR: 1.6; 95% CI: 1.4–1.7), black ethnicity (OR: 1.9; 95% CI: 1.7–2.1) and heterosexual transmission group (OR:1.8; 95% CI: 1.6–2.0), were all associated with underrepresentation in the SHCS. We found 344 purely non-SHCS transmission clusters, however, these outbreaks were small (median 2, maximum 7 patients) with a strong overlap with the SHCS’. 65% of non-SHCS sequences were part of clusters composed of >= 50% SHCS sequences. Our data suggests that marginalized-populations are underrepresented in the SHCS. However, the limited size of outbreaks among non-SHCS patients in-care implies that no major HIV outbreak in Switzerland was missed by the SHCS surveillance. This study demonstrates the potential of sequence data to assess and extend the scope of infectious-disease surveillance. |
| وصف الملف: | application/pdf; srep27580.pdf - application/pdf |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26d15ffd774497093707bfc97413e035Test https://doi.org/10.1038/srep27580Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....26d15ffd774497093707bfc97413e035 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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