Cutaneous T-cell-attracting chemokine as a novel biomarker for predicting prognosis of idiopathic pulmonary fibrosis: a prospective observational study
| العنوان: | Cutaneous T-cell-attracting chemokine as a novel biomarker for predicting prognosis of idiopathic pulmonary fibrosis: a prospective observational study |
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| المؤلفون: | Yuko Murase, Akihiko Yoshizawa, Kiminobu Tanizawa, Toyohiro Hirai, Izumi Yamaguchi, Masahito Emura, Tomohiro Handa, Hiromi Tomioka, Kazuko Uno, Yoshio Taguchi, Naoki Arai, Yoshinari Nakatsuka, Takafumi Niwamoto, Machiko Arita, Keisuke Tomii, Michihiro Uyama, Tetsuji Kawamura, Fumihiko Matsuda, Ryuji Uozumi, Kazuo Chin, Hideo Kita, Michiko Tsuchiya |
| المصدر: | Respiratory Research Respiratory Research, Vol 22, Iss 1, Pp 1-11 (2021) |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Oncology, Chemokine, CC chemokine receptor 10, medicine.medical_treatment, Idiopathic pulmonary fibrosis, 0302 clinical medicine, Medicine, Prospective Studies, Macrophage inflammatory protein, Multiplex, biology, CTACK, respiratory system, Middle Aged, Prognosis, Cytokine, medicine.anatomical_structure, Disease Progression, Biomarker (medicine), Female, Adult, medicine.medical_specialty, Diseases of the respiratory system, 03 medical and health sciences, Internal medicine, Humans, Aged, Lung, RC705-779, business.industry, Chemokine CCL27, Research, Biomarker, medicine.disease, Cutaneous T-cell-attracting chemokine, respiratory tract diseases, IPF, 030104 developmental biology, 030228 respiratory system, CCL27, biology.protein, business, CC chemokine receptors, Biomarkers |
| الوصف: | Background Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrotic lung disease that leads to respiratory failure and death. Although there is a greater understanding of the etiology of this disease, accurately predicting the disease course in individual patients is still not possible. This study aimed to evaluate serum cytokines/chemokines as potential biomarkers that can predict outcomes in IPF patients. Methods A multi-institutional prospective two-stage discovery and validation design using two independent cohorts was adopted. For the discovery analysis, serum samples from 100 IPF patients and 32 healthy controls were examined using an unbiased, multiplex immunoassay of 48 cytokines/chemokines. The serum cytokine/chemokine values were compared between IPF patients and controls; the association between multiplex measurements and survival time was evaluated in IPF patients. In the validation analysis, the cytokines/chemokines identified in the discovery analysis were examined in serum samples from another 81 IPF patients to verify the ability of these cytokines/chemokines to predict survival. Immunohistochemical assessment of IPF-derived lung samples was also performed to determine where this novel biomarker is expressed. Results In the discovery cohort, 18 cytokines/chemokines were significantly elevated in sera from IPF patients compared with those from controls. Interleukin-1 receptor alpha (IL-1Rα), interleukin-8 (IL-8), macrophage inflammatory protein 1 alpha (MIP-1α), and cutaneous T-cell-attracting chemokine (CTACK) were associated with survival: IL-1Rα, hazard ratio (HR) = 1.04 per 10 units, 95% confidence interval (95% CI) 1.01–1.07; IL-8, HR = 1.04, 95% CI 1.01–1.08; MIP-1α, HR = 1.19, 95% CI 1.00–1.36; and CTACK, HR = 1.12 per 100 units, 95% CI 1.02–1.21. A replication analysis was performed only for CTACK because others were previously reported to be potential biomarkers of interstitial lung diseases. In the validation cohort, CTACK was associated with survival: HR = 1.14 per 100 units, 95% CI 1.01–1.28. Immunohistochemistry revealed the expression of CTACK and CC chemokine receptor 10 (a ligand of CTACK) in airway and type II alveolar epithelial cells of IPF patients but not in those of controls. Conclusions CTACK is a novel prognostic biomarker of IPF. Trial registration None (because of no healthcare intervention) |
| وصف الملف: | application/pdf |
| تدمد: | 1465-993X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66c472e91a82209cb745f09a241f8acfTest https://doi.org/10.1186/s12931-021-01779-9Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....66c472e91a82209cb745f09a241f8acf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1465993X |
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