دورية أكاديمية
Characteristics, management, and prognosis of elderly patients with COVID-19 admitted in the ICU during the first wave: insights from the COVID-ICU study : Prognosis of COVID-19 elderly critically ill patients in the ICU.
| العنوان: | Characteristics, management, and prognosis of elderly patients with COVID-19 admitted in the ICU during the first wave: insights from the COVID-ICU study : Prognosis of COVID-19 elderly critically ill patients in the ICU. |
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| المؤلفون: | Dres, Martin, Hajage, David, Lebbah, Said, Kimmoun, Antoine, Pham, Tai, Béduneau, Gaëtan, Combes, Alain, Mercat, Alain, Guidet, Bertrand, Demoule, Alexandre, Schmidt, Matthieu, COVID-ICU investigators |
| المساهمون: | Lambermont, Bernard |
| المصدر: | Annals of Intensive Care, 11 (1), 77 (2021-05-14) |
| بيانات النشر: | Springer Science and Business Media Deutschland GmbH |
| سنة النشر: | 2021 |
| المجموعة: | University of Liège: ORBi (Open Repository and Bibliography) |
| مصطلحات موضوعية: | Acute respiratory distress syndrome, COVID-19, Frailty, Intensive care unit, Intubation, Mortality, Old patients, Critical Care and Intensive Care Medicine, Human health sciences, Anesthesia & intensive care, Sciences de la santé humaine, Anesthésie & soins intensifs |
| الوصف: | peer reviewed ; [en] BACKGROUND: The COVID-19 pandemic is a heavy burden in terms of health care resources. Future decision-making policies require consistent data on the management and prognosis of the older patients (> 70 years old) with COVID-19 admitted in the intensive care unit (ICU). METHODS: Characteristics, management, and prognosis of critically ill old patients (> 70 years) were extracted from the international prospective COVID-ICU database. A propensity score weighted-comparison evaluated the impact of intubation upon admission on Day-90 mortality. RESULTS: The analysis included 1199 (28% of the COVID-ICU cohort) patients (median [interquartile] age 74 [72-78] years). Fifty-three percent, 31%, and 16% were 70-74, 75-79, and over 80 years old, respectively. The most frequent comorbidities were chronic hypertension (62%), diabetes (30%), and chronic respiratory disease (25%). Median Clinical Frailty Scale was 3 (2-3). Upon admission, the PaO2/FiO2 ratio was 154 (105-222). 740 (62%) patients were intubated on Day-1 and eventually 938 (78%) during their ICU stay. Overall Day-90 mortality was 46% and reached 67% among the 193 patients over 80 years old. Mortality was higher in older patients, diabetics, and those with a lower PaO2/FiO2 ratio upon admission, cardiovascular dysfunction, and a shorter time between first symptoms and ICU admission. In propensity analysis, early intubation at ICU admission was associated with a significantly higher Day-90 mortality (42% vs 28%; hazard ratio 1.68; 95% CI 1.24-2.27; p < 0·001). CONCLUSION: Patients over 70 years old represented more than a quarter of the COVID-19 population admitted in the participating ICUs during the first wave. Day-90 mortality was 46%, with dismal outcomes reported for patients older than 80 years or those intubated upon ICU admission. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2110-5820 |
| العلاقة: | https://link.springer.com/content/pdf/10.1186/s13613-021-00861-1.pdfTest; urn:issn:2110-5820; https://orbi.uliege.be/handle/2268/300781Test; info:hdl:2268/300781; https://orbi.uliege.be/bitstream/2268/300781/1/Characteristics%2c%20management%2c%20and%20prognosis%20of%20elderly%20patients%20with%20COVID%2019%20admitted%20in%20the%20ICU%20during%20the%20first%20wave_%20insights%20from%20the%20COVID%20ICU%20study.pdfTest; scopus-id:2-s2.0-85107194274; info:pmid:33988767 |
| DOI: | 10.1186/s13613-021-00861-1 |
| الإتاحة: | https://doi.org/10.1186/s13613-021-00861-1Test https://orbi.uliege.be/handle/2268/300781Test https://orbi.uliege.be/bitstream/2268/300781/1/Characteristics%2c%20management%2c%20and%20prognosis%20of%20elderly%20patients%20with%20COVID%2019%20admitted%20in%20the%20ICU%20during%20the%20first%20wave_%20insights%20from%20the%20COVID%20ICU%20study.pdfTest |
| حقوق: | open access ; http://purl.org/coar/access_right/c_abf2Test ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.9C880832 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 21105820 |
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| DOI: | 10.1186/s13613-021-00861-1 |