دورية أكاديمية
Precise localization of antigens on follicular dendritic cells.
| العنوان: | Precise localization of antigens on follicular dendritic cells. |
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| المؤلفون: | Radoux, D., Heinen, Ernst, Kinet-Denoel, C., Tihange, E., Simar, L. |
| المصدر: | Cell and Tissue Research, 235 (2), 267-74 (1984) |
| بيانات النشر: | Springer Science & Business Media B.V., 1984. |
| سنة النشر: | 1984 |
| مصطلحات موضوعية: | Animals, Antigens, Surface/analysis, Female, Ferritins, Gold, Lymph Nodes/immunology/ultrastructure, Lymphocytes/immunology/ultrastructure, Mice, Mice, Inbred C57BL, Microscopy, Electron, Serum Albumin, Life sciences, Anatomy (cytology, histology, embryology...) & physiology, Sciences du vivant, Anatomie (cytologie, histologie, embryologie...) & physiologie |
| الوصف: | Horse-spleen ferritin or bovine serum albumin conjugated to colloidal gold (BSA-gold) were injected subcutaneously in preimmunized mice. In draining lymph nodes both antigens were located in macrophages or between the cytoplasmic processes of follicular dendritic cells (FDC). Some of the antigens remained trapped on FDC until day 31 after injection. Simultaneous injection of both antigens showed that they were located between the infoldings of the same FDC. These cells are thus able to retain at least two different antigens on their surface. The peculiar arrangement of ferritin between the cytoplasmic infoldings suggests that this antigen is fixed on both cell membranes by specific antibodies. The trapped immune complexes could thus stabilize the FDC membrane system. The antigen retention requires the presence of specific antibodies since BSA-gold or ferritin injected without preimmunization were not found between FDC processes. Nonantigenic materials, such as colloidal gold or carbon particles, are not trapped by FDC, except when injected in large amounts. The antigens were trapped on the surface of FDC, however unfrequently in close contact with lymphocytes. FDC might protect lymphocytes against an excess of immune complexes and act as regulators of contacts between lymphocytes and immune complexes. |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501Test article |
| اللغة: | English |
| العلاقة: | urn:issn:0302-766X; urn:issn:1432-0878 |
| DOI: | 10.1007/BF00217850 |
| الوصول الحر: | https://orbi.uliege.be/handle/2268/23228Test |
| رقم الانضمام: | edsorb.23228 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.1007/BF00217850 |
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