دورية أكاديمية
Chilean registry for neuroendocrine tumors: a Latin American perspective
| العنوان: | Chilean registry for neuroendocrine tumors: a Latin American perspective |
|---|---|
| المؤلفون: | Pinto, Mauricio P., Muñoz Medel, Matías, Carrillo, Diego, Retamal, Ignacio N., Bravo, M. Loreto, Valenzuela, Yasna, Nervi, Bruno, Sánchez, César, Galindo, Héctor, Ibañez, Carolina, Peña, José, Balmaceda, Carlos, Madrid, Jorge, Briones, Juan, Torres, Javiera, Nilo, Flavia, Guarda, Francisco J., Quintana, Juan Carlos, Orellana, Pilar, Mondaca, Sebastián, Acevedo, Francisco, Vicentini, Daniel, Cordova-Delgado, Miguel, Owen, Gareth I., Garrido, Marcelo |
| بيانات النشر: | Springer New York |
| سنة النشر: | 2019 |
| المجموعة: | The University of Queensland: UQ eSpace |
| مصطلحات موضوعية: | Cancer registry, Chromogranin A, Neuroendocrine tumors, Overall survival, 1306 Cancer Research, 1310 Endocrinology, 2712 Endocrinology, Diabetes and Metabolism, 2730 Oncology, 2807 Endocrine and Autonomic Systems |
| الوصف: | Neuroendocrine tumors (NETs) are relatively rare and highly heterogeneous neoplasms. Despite this, recent studies from North America and Central Europe have suggested an increase in incidence. In Latin America, NET data are scarce and scattered with only a few studies reporting registries. Our goal was to establish a NET registry in Chile. Here, we report the establishment and our first 166 NET patients. We observed a slight preponderance of males, a median age at diagnosis of 53 years and a median overall survival of 110 months. As anticipated, most tumors were gastroenteropancreatic (GEP). Survival analyses demonstrated that non-GEP or stage IV tumors presented significantly lower overall survival (OS). Similarly, patients with surgery classified as R0 had better OS compared to R1, R2, or no surgery. Furthermore, patients with elevated chromogranin A (CgA) or high Ki67 showed a trend to poorer OS; however, these differences did not reach statistical significance (log-rank test p = 0.07). To the best of our knowledge, this is the first report of a NET registry in Chile. Median OS in our registry (110 months) is in line with other registries from Argentina and Spain. Other variables including age at diagnosis and gender were similar to previous studies; however, our data indicate a high proportion of small-bowel NETs compared to other cohorts, reflecting the need for NET regional registries. Indeed, these registries may explain regional discrepancies in incidence and distribution, adding to our knowledge on this seemingly rare, highly heterogeneous disease. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1868-8500 1868-8497 |
| العلاقة: | orcid:0000-0002-8216-4353; Not set; 1180173; 1180241; CONICYT-FONDAP 15130011; IMII P09/016-F |
| الإتاحة: | https://doi.org/10.1007/s12672-018-0354-5Test https://espace.library.uq.edu.au/view/UQ:a1bff5aTest |
| رقم الانضمام: | edsbas.1FF50658 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 18688500 18688497 |
|---|