Transcription factor 7-like 2 (TCF7L2) gene polymorphism and clinical phenotype in end-stage renal disease patients
| العنوان: | Transcription factor 7-like 2 (TCF7L2) gene polymorphism and clinical phenotype in end-stage renal disease patients |
|---|---|
| المؤلفون: | Monika Buraczynska, Wojciech Załuska, Agata Kuczmaszewska, Piotr Ksiazek, Pawel Zukowski, Joanna Janicka |
| المصدر: | Molecular Biology Reports |
| بيانات النشر: | Springer Netherlands, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, endocrine system diseases, Single-nucleotide polymorphism, Diabetic nephropathy, Biology, Gastroenterology, Article, End stage renal disease, End-stage renal disease, Gene Frequency, Risk Factors, Internal medicine, Diabetes mellitus, Genotype, Genetics, medicine, Humans, Diabetic Nephropathies, Genetic Predisposition to Disease, Allele, Molecular Biology, Allele frequency, Aged, Risk allele, General Medicine, Middle Aged, medicine.disease, Cardiovascular disease, Single nucleotide polymorphism, Endocrinology, Diabetes Mellitus, Type 2, Cardiovascular Diseases, Kidney Failure, Chronic, Female, TCF7L2, Transcription Factor 7-Like 2 Protein |
| الوصف: | Variants of the transcription factor 7-like 2 gene (TCF7L2) have been associated with type 2 diabetes and cardiovascular disease in different populations. Here we investigated the potential association of the rs7903146 polymorphism in the TCF7L2 gene with clinical profile of end-stage renal disease (ESRD) patients. We examined a cohort of 1065 ESRD patients with diabetic and non-diabetic renal disease. The control group consisted of 924 healthy individuals. All subjects were genotyped for the rs7903146 single nucleotide polymorphism by polymerase chain reaction. The genotype distribution and allele frequencies were significantly different between ESRD patients and controls (p |
| اللغة: | English |
| تدمد: | 1573-4978 0301-4851 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be113ad5b626df3ade08d8384abc8550Test http://europepmc.org/articles/PMC4033800Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....be113ad5b626df3ade08d8384abc8550 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15734978 03014851 |
|---|