دورية أكاديمية
Cost-effective analysis of candidate genes using htSNPs: a staged approach.
| العنوان: | Cost-effective analysis of candidate genes using htSNPs: a staged approach. |
|---|---|
| المؤلفون: | Lowe, CE, Cooper, JD, Chapman, JM, Barratt, BJ, Twells, RCJ, Green, EA, Savage, DA, Guja, C, Ionescu-Tîrgovişte, C, Tuomilehto-Wolf, E, Tuomilehto, J, Todd, JA, Clayton, DG |
| بيانات النشر: | Springer Nature [academic journals on nature.com] |
| سنة النشر: | 2004 |
| المجموعة: | London School of Hygiene & Tropical Medicine: LSHTM Research Online |
| الوصف: | We have previously shown that the selection of haplotype tag single nucleotide polymorphisms (htSNPs) and their statistical analysis in a multi-locus transmission/disequilibrium test (TDT) results in a more cost-effective genotyping strategy in disease association studies of genes by minimising redundancy due to linkage disequilibrium between SNPs. Further savings can be achieved by the use of a two-stage genotyping strategy. This approach is illustrated here in conjunction with the multi-locus TDT in determining whether common alleles of the immune regulatory genes RANK and its ligand TRANCE (RANKL) are associated with type 1 diabetes (T1D). A saving of approximately 75% of potential genotyping reactions could be made with minimal loss of power. There was little evidence from our analysis for association between the TRANCE and RANK genes and T1D in the populations tested. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | Lowe, CE; Cooper, JD; Chapman, JM; Barratt, BJ; Twells, RCJ; Green, EA; Savage, DA; Guja, C; Ionescu-Tîrgovişte, C; Tuomilehto-Wolf, E; +3 more. Tuomilehto, J; Todd, JA; Clayton, DG; (2004) Cost-effective analysis of candidate genes using htSNPs: a staged approach. Genes and immunity, 5 (4). pp. 301-305. ISSN 1466-4879 DOI: https://doi.org/10.1038/sj.gene.6364064Test |
| الإتاحة: | https://doi.org/10.1038/sj.gene.6364064Test https://researchonline.lshtm.ac.uk/id/eprint/11281Test/ |
| رقم الانضمام: | edsbas.ACFC1685 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |