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A multi-ethnic study of a PNPLA3 gene variant and its association with disease severity in non-alcoholic fatty liver disease

التفاصيل البيبلوغرافية
العنوان: A multi-ethnic study of a PNPLA3 gene variant and its association with disease severity in non-alcoholic fatty liver disease
المؤلفون: Sanjiv Mahadeva, Phaik-Leng Cheah, Rosmawati Mohamed, Roma Choudhury Basu, Shamsul Mohd Zain, Sanjay Rampal, Zahurin Mohamed
المصدر: Human Genetics
بيانات النشر: Springer Nature
مصطلحات موضوعية: Liver Cirrhosis, Male, medicine.medical_specialty, Genotype, Biology, Polymorphism, Single Nucleotide, Gastroenterology, Body Mass Index, Gene Frequency, Non-alcoholic Fatty Liver Disease, Internal medicine, Biopsy, medicine, Genetics, Humans, Genetic Predisposition to Disease, Adiponutrin, Genetics(clinical), education, Allele frequency, Alleles, Triglycerides, Genetics (clinical), Original Investigation, education.field_of_study, medicine.diagnostic_test, Fatty liver, Case-control study, Genetic Variation, Membrane Proteins, nutritional and metabolic diseases, Lipase, Middle Aged, medicine.disease, digestive system diseases, Fatty Liver, Liver, Case-Control Studies, Female, Gene polymorphism, Steatohepatitis, Body mass index
الوصف: The adiponutrin (PNPLA3) rs738409 polymorphism has been found to be associated with susceptibility to non-alcoholic fatty liver disease (NAFLD) in various cohorts. We further investigated the association of this polymorphism with non-alcoholic steatohepatitis (NASH) severity and with histological features of NAFLD. A total of 144 biopsy-proven NAFLD patients and 198 controls were genotyped for PNPLA3 gene polymorphism (rs738409 C>G). The biopsy specimens were histologically graded by a qualified pathologist. We observed an association of G allele with susceptibility to NAFLD in the pooled subjects (OR 2.34, 95% CI 1.69–3.24, p
اللغة: English
تدمد: 0340-6717
DOI: 10.1007/s00439-012-1141-y
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cf8fbb5935599498449596266d80b47Test
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....2cf8fbb5935599498449596266d80b47
قاعدة البيانات: OpenAIRE
الوصف
تدمد:03406717
DOI:10.1007/s00439-012-1141-y