المؤلفون: Gillis, Katrin, van Diermen, Linda, Lahaye, Hilde, De Witte, Marianne, De Wit, Yentl, Roelant, Ella, Lips, Dirk, Zhiri, Abdesselam, Hockley, Jo, Van Bogaert, Peter

المصدر: European Geriatric Medicine; Oct2023, Vol. 14 Issue 5, p1083-1096, 14p

مستخلص: Key summary points: Aim: To evaluate to what extent the standardized concept of need-based care on Behavioural and Psychological Symptoms of Dementia (BPSD), and formal caregiver distress, is superior when compared to spending more time or standard care with residents with BPSD. Findings: Need-based interventions had a significant effect on residents' levels of pain behaviour. In the need-based care group, scores on overall BPSD (agitation and aggression, depression, euphoria, irritability, sleep and night-time behaviour) improved significantly from baseline when compared to other timepoints. Message: Tailored non-pharmacological interventions in the residential care for people with dementia reduce the level of BPSD and formal caregivers' distress. Purpose: To evaluate to what extent the standardized concept of need-based care on Behavioural and Psychological Symptoms of Dementia (BPSD), and formal caregiver distress, is superior when compared to spending more time or standard care with residents with BPSD. Methods: A longitudinal cluster randomized controlled study in 23 nursing homes in Belgium with 3 parallel groups was set up. A total of 481 residents with dementia participated. Formal caregivers in the need-based care group treated residents who displayed agitated or aggressive behaviour with a non-pharmacological intervention, tailored to unmet needs, twice a week with re-evaluation every 8 weeks. In the time group, formal caregivers spent 'extra time'. In the standard care group, it was 'care as usual'. Outcomes were measured at four different time points with the Doloplus-2 (to assess pain behaviour), Cohen-Mansfield Agitation Inventory (CMAI) for agitation, the Neuropsychiatric Inventory (NPI-NH) for BPSD and formal caregivers' distress. Results: Need-based interventions had a significant effect on residents' levels of pain behaviour. In the need-based care group, scores on overall BPSD (agitation and aggression, depression, euphoria, irritability, sleep and night-time behaviour) improved significantly from baseline when compared to other timepoints. No significant different interactions over time were found between all three groups for categorized versions of NPI scores (ever versus never). Conclusion: Need-based care reduced the level of BPSD in residents with dementia as well as formal caregivers' distress. The study supports the importance of tailored non-pharmacological interventions in the residential care for people with dementia. Trial Registry: Trial registration number B300201942084 (18/11/2019). [ABSTRACT FROM AUTHOR]

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المؤلفون: FOULON, M., AEBY, A., BUZATU, M., CHRISTIAENS, F., DE BORCHGRAVE, V., DE COCQ, C., DE TOURTCHANINOFF, M., DUBRU, J. M., GHARIANI, S., GRISAR, T., LEGROS, B., LIENARD, F., OSSEMANN, M., TUGENDHAFT, P., VAN BOGAERT, P., VAN RIJCKEVORSEL, K., VERHEULPEN, D., VRIELYNCK, P.

المصدر: Acta Neurologica Belgica; Sep2011, Vol. 111 Issue 3, p175-182, 8p

العنوان البديل: [Cerebral functions in brain-damaged patients. What is meant by coma, vegetative state, minimally conscious state, locked-in syndrome and brain death?]. (English)

المؤلفون: Faymonville, M-E, Pantke, K-H, Berré, J, Sadzot, B, Ferring, M, de Tiège, X, Mavroudakis, N, van Bogaert, P, Lambermont, B, Damas, P, Franck, G, Lamy, M, Luxen, A, Moonen, G, Goldman, S, Maquet, P, Laureys, S

المصدر: Anaesthesist; Dec2004, Vol. 53 Issue 12, p1195-1202, 8p

مستخلص: Comatose, vegetative, minimally conscious or locked-in patients represent a problem in terms of diagnosis, prognosis, treatment and everyday management at the intensive care unit. The evaluation of possible cognitive functions in these patients is difficult because voluntary movements may be very small, inconsistent and easily exhausted. Functional neuroimaging cannot replace the clinical assessment of patients with altered states of consciousness. Nevertheless, it can describe objectively how deviant from normal the cerebral activity is and its regional distribution at rest and under various conditions of stimulation. The quantification of brain activity differentiates patients who sometimes only differ by a brief and incomplete blink of an eye. In the present paper, we will first try to define consciousness as it can be assessed at the patient's bedside. We then review the major clinical entities of altered states of consciousness encountered in the intensive care unit. Finally, we discuss the functional neuroanatomy of these conditions as assessed by positron emission tomography (PET) scanning. [ABSTRACT FROM AUTHOR]

: Copyright of Anaesthesist is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Raes, A., Wang, Z., van den Berg, R. J., Goethals, M., de Vijver, G. Van, van Bogaert, P. P.

المصدر: Pflügers Archiv: European Journal of Physiology; Aug1997, Vol. 434 Issue 5, p543-550, 8p

مستخلص: In mouse dorsal root ganglion (DRG) neurons the activation curve of the hyperpolarization-activated current ( Ih) shifted towards depolarized potentials when cAMP was present in the pipette. The relation between the midpoint potential and cAMP concentration could be described by a Hill function with a half-maximal concentration of 0.55 μM cAMP, reflecting a direct action of cAMP on the channel. With 5 mM ATP and a saturating concentration of cAMP an additional shift of the midpoint potential is observed which can be explained by phosphorylation. Application of Rp-cAMPS and Sp-cAMPS support the hypothesis of both a phosphorylation pathway and a direct effect exhibited by these molecules. The bell-shaped curves, relating the time constants for the slow and fast current components to the voltage, shifted towards positive membrane potentials when cAMP and ATP were in the pipette. The fully activated Ih/voltage relation and the reversal potential were not dependent on the presence of cAMP or ATP in the pipette. The mean resting membrane potential of –59 mV, using the perforated-patch configuration, hyperpolarized in the presence of extracellular CsCl. In the whole-cell configuration the resting membrane potential was significantly more negative at 0 μM cAMP (–61 mV) than at 100 μM cAMP (–57 mV). Thus, the activation of Ih, regulated by both the intracellular cAMP and the ATP concentration, may influence the excitability of DRG neurons. [ABSTRACT FROM AUTHOR]

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المؤلفون: Rypens, F., Avni, E., Dussaussois, L., David, P., Vermeylen, P., Bogaert, P., Matos, C., Rypens, E, Avni, E F, Vermeylen, D, van Bogaert, P

المصدر: Pediatric Radiology; Dec1994, Vol. 24 Issue 8, p550-553, 4p

مستخلص: In the neonate, hyperechoic thickening of the ependyma is believed to be related to ventriculitis. Yet, in our experience, this sign is much more often observed in association with subacute intraventricular hemorrhage (IVH), without infection. Sixty premature neonates were prospectively studied. The observations of transfontanellar sonograms (intracranial hemorrhage, ependymal echogenicity, and ventriculomegaly) were correlated with the results of MRI, lumbar punctures and clinical work-up. Intracranial hemorrhage was detected in 28 patients, and hyperechoic thickening of the ependyma was observed in 21 of them, all of whom had IVH. In 9 of these 21 patients IVH was diagnosed retrospectively thanks to the visualization of the hyperechoic ependyma. In all but one, this sign persisted for at least 2 months after disappearance of other signs of IVH. MRI demonstrated the presence of hemosiderin and ferritin in ependymal or subependymal location only in patients with hyperechoic ependyma. One of our patients had in utero diagnosis of IVH owing to the visualization of the same hyperechoic aspect of the ependyma. Nine of the neonates with hyperechoic ependyma developed ventriculomegaly, and three underwent surgery. Hyperechoic thickening of the ependyma in prematures often results from a subacute IVH. It is related to hemoglobin catabolites which can be detected by MRI. It does not require immediate potentially harmful diagnostic punctures. The presence of this hyperechoic rim allows a retrospective diagnosis of IVH and indicates a clinical and sonographic follow-up in newborns at risk for secondary hydrocephalus. [ABSTRACT FROM AUTHOR]

: Copyright of Pediatric Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)