BMC, Ed., Institute of Biomedical Sciences, Universidade de São Paulo = University of São Paulo (USP), Tolérance Immunitaire (EA 6302), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Research and Development, Stallergenes SA, Unité d'Immuno-Allergie Alimentaire (UIAA - UR 496), Institut National de la Recherche Agronomique (INRA), Institut de Biologie et de Technologies de Saclay (IBITECS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Epidémiologie des maladies infectieuses et modélisation (ESIM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), School of Pediatrics and Child Health, The University of Western Australia (UWA), The International Inflammation 'in-FLAME' Network, Worldwide Universities Network (WUN)
Results Der p 1 was present in 58% Brazilian, 70% French, and 78% Australian colostrum. Median [Der p 1] was similar between countries (96 pg/mL). In mature milk, Der p1 was found in 55% of samples, median [Der p 1] was 65·9 pg/mL and was significantly lower than in colostrum (p=0·0001). Der p 1-containing milks were able to induce basophils degranulation. Mice breastfed by Der p-exposed mothers had 5-fold increased levels of Der p specific IgE and IgG1 compared to mice breastfed by naive mothers. Their allergic airway inflammation was not affected.
