كتاب
T-tubule remodelling and ryanodine receptor organization modulate sodium-calcium exchange
العنوان: | T-tubule remodelling and ryanodine receptor organization modulate sodium-calcium exchange |
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المؤلفون: | Sipido, Karin R., Acsai, Károly, Antoons, Gudrun, Bito, Virginie, Macquaide, Niall |
المصدر: | Sipido , K R , Acsai , K , Antoons , G , Bito , V & Macquaide , N 2013 , T-tubule remodelling and ryanodine receptor organization modulate sodium-calcium exchange . in Sodium Calcium Exchange: A Growing Spectrum of Pathophysiological Implications . vol. 961 , Advances in Experimental Medicine and Biology , Springer Nature , pp. 375-383 . https://doi.org/10.1007/978-1-4614-4756-6_32Test |
بيانات النشر: | Springer Nature |
سنة النشر: | 2013 |
مصطلحات موضوعية: | Animals, Calcium/metabolism, Calcium Channels, L-Type/genetics, Humans, Muscle Proteins/genetics, Myocytes, Cardiac/metabolism, Ryanodine Receptor Calcium Release Channel/genetics, Sarcoplasmic Reticulum/genetics, Sodium/metabolism, Sodium-Calcium Exchanger/genetics |
الوصف: | The Na(+)/Ca(2+) exchanger (NCX) is a key regulator of intracellular Ca(2+) in cardiac myocytes, predominantly contributing to Ca(2+) removal during the diastolic relaxation process but also modulating excitation-contraction coupling. NCX is preferentially located in the T-tubules and can be close to or within the dyad, where L-type Ca(2+) channels face ryanodine receptors (RyRs), the Ca(2+) release channels of the sarcoplasmic reticulum. However, especially in larger animals, not all RyRs are in dyads or adjacent to T-tubules, and a substantial fraction of Ca(2+) release from the sarcoplasmic reticulum thus occurs at distance from NCX. This chapter deals with the functional consequences of NCX location and how NCX can modulate diastolic and systolic Ca(2+) events. The loss of T-tubules and the effects on RyR function and NCX modulation are explored, as well as quantitative measurement of local Ca(2+) gradients at the level of the dyadic space. |
نوع الوثيقة: | book part |
اللغة: | English |
ردمك: | 978-1-4614-4755-9 1-4614-4755-0 |
العلاقة: | https://researchonline.gcu.ac.uk/en/publications/70c8c117-38ca-41d7-ab5a-683e51f20786Test; urn:ISBN:9781461447559 |
DOI: | 10.1007/978-1-4614-4756-6_32 |
الإتاحة: | https://doi.org/10.1007/978-1-4614-4756-6_32Test https://researchonline.gcu.ac.uk/en/publications/70c8c117-38ca-41d7-ab5a-683e51f20786Test |
حقوق: | info:eu-repo/semantics/restrictedAccess |
رقم الانضمام: | edsbas.B88AFD34 |
قاعدة البيانات: | BASE |
ردمك: | 9781461447559 1461447550 |
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DOI: | 10.1007/978-1-4614-4756-6_32 |