التفاصيل البيبلوغرافية
| العنوان: |
Key components of the fission machinery are interchangeable. |
| المؤلفون: |
Jia-Shu Yang1, Leiliang Zhang1, Lee, Stella Y.1, Gad, Helge2, Luini, Alberto2, Hsu, Victor W.1 vhsu@rics.bwh.harvard.edu |
| المصدر: |
Nature Cell Biology. Dec2006, Vol. 8 Issue 12, p1376-1382. 7p. 8 Graphs. |
| مصطلحات موضوعية: |
*CELLULAR signal transduction, *PROTEINS, *FISSION (Asexual reproduction), *MEMBRANE proteins, *BIOLOGICAL membranes, *DYNAMIN (Genetics) |
| مستخلص: |
Brefeldin-A ADP-ribosylated substrate (BARS) and dynamin function in membrane fission in distinct intracellular transport pathways, but whether their functions are mechanistically similar is unclear. Here, we show that ARFGAP1, a GTPase-activating protein (GAP) for ADP-ribosylation factor 1 (ARF1), couples to either BARS or endophilin B for vesicle formation by the coat protein I (COPI) complex — a finding that reveals an unanticipated mechanistic flexibility in mammalian COPI transport. Because dynamin is coupled to endophilin A in vesicle formation by the clathrin-coat complex, our finding also predicts that dynamin and ARF GAPs are likely to be functional counterparts in membrane fission among different transport pathways that connect intracellular membrane compartments. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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