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1دورية أكاديميةSpanish validation of the self-evaluation of negative symptoms scale SNS in an adolescent population
المؤلفون: Rodríguez Testal, Juan Francisco, Perona Garcelán, Salvador Félix, Dollfus, Sonia, Valdés Díaz, María, García Martínez, Jesús, Ruiz Veguilla, Miguel, Senín Calderón, María Cristina
المساهمون: Universidad de Sevilla. Departamento de Personalidad, Evaluación y Tratamiento Psicológicos, Ministerio de Economía y Competitividad (MINECO). España, European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) PSI2015–68659-P
مصطلحات موضوعية: Negative symptoms, Adolescence, SNS, Psychosis, General population
الوصف: Background Negative symptoms (NS) may be observed in the general population in an attenuated form and in high-risk mental states. However, they have been less studied in the general population than positive symptoms, in spite of their importance at the insidious onset of schizophrenia and their appearance before positive symptoms. This study aimed to analyze the empirical structure of the Spanish version of the Self-Evaluation of Negative Symptoms (SNS) Scale and find its psychometric properties and invariance of measurement across sex and age in a sample of adolescents. Methods The sample consisted of 4521 adolescents (53.6% female) from 11 to 18 years of age. Results Confirmatory Factor Analysis of the SNS confirmed an internal structure of five first-order factors by the characteristic dimensions of NS: avolition, social withdrawal, diminished emotional range, anhedonia, alogia, and one second-order factor which includes the total NS score. Multi-group confirmatory factor analysis showed that the scale was invariant across sex and age. Total scale reliability was adequate. A strong relationship was found between the SNS with depressive symptomatology, moderate with ideas of reference and low with aberrant salience. Conclusion: The results back use of the Spanish version of the SNS scale for detection of NS in the general population of adolescents.
العلاقة: BMC Psychiatry, 19, Article 327-.; PSI2015–68659-P; https://doi.org/10.1186/s12888-019-2314-1Test; https://idus.us.es/handle//11441/94661Test
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2دورية أكاديمية
المصدر: Journal of Molecular Evolution; Feb2005, Vol. 60 Issue 2, p174-182, 9p
مصطلحات موضوعية: NUCLEIC acids, GENETIC transduction, PLASMIDS, GENOMICS, GENOMES, DNA
مستخلص: Prokaryotes contain short DNA repeats known as CRISPR, recognizable by the regular spacing existing between the recurring units. They represent the most widely distributed family of repeats among prokaryotic genomes, suggesting a biological function. The origin of the intervening sequences, at present unknown, could provide clues about their biological activities. Here we show that CRISPR spacers derive from preexisting sequences, either chromosomal or within transmissible genetic elements such as bacteriophages and conjugative plasmids. Remarkably, these extrachromosomal elements fail to infect the specific spacer-carrier strain, implying a relationship between CRISPR and immunity against targeted DNA. Bacteriophages and conjugative plasmids are involved in prokaryotic population control, evolution, and pathogenicity. All these biological traits could be influenced by the presence of specific spacers. CRISPR loci can be visualized as mosaics of a repeated unit, separated by sequences at some time present elsewhere in the cell. [ABSTRACT FROM AUTHOR]
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